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Ethanol is the type of alcohol found in alcoholic beverages. It is a volatile, flammable, colorless liquid that acts as a central nervous system depressant. Ethanol can impair different types of memory.



Neurochemistry
Alcohol acts as a positive allosteric modulator of gamma-aminobutyric acid (GABA) receptors, specifically the GABAA subtype. Upon activation, these GABA receptors conduct Cl-, resulting in neuronal hyperpolarization. This hyperpolarization decreases the chance of an action potential occuring and thus has an inhibitory effect on neurotransmission of the central nervous system.

At higher doses, ethanol also affects NMDA receptors by inhibiting the ion current induced by N-methyl-D-aspartate (NMDA), a glutamate receptor agonist. This prevents excitatory synaptic transmissions from occurring, affecting synaptic plasticity and in turn, memory and learning.

Neurophysiology
Alcohol acts as a general central nervous system depressant, but it also affects specific areas of the brain to a more profound degree than others. At higher doses, it significantly inhibits neuronal activity in the CA1 and CA3 pyramidal cell layers of the hippocampus. This impairs memory encoding since the hippocampus plays an important role in the formation of new memories. Alcohol also impairs and alters functioning in the cerebellum, which affects motor function and coordination. It has a notable inhibitory effect on neurons of the cerebral cortex, affecting and altering thought processes, decreasing inhibition, and increasing the pain threshold. It also decreases sexual performance by depressing nerve centres in the hypothalamus. Alcohol also has an effect on urine excretion via inhibition of anti-diuretic hormone (ADH) secretion of the pituitary gland. Lastly, it depresses breathing and heart rate by inhibiting neuronal functioning of the medulla.

Long Term Memory
Long-term memory (LTM) has a long duration and large capacity. Memories stored in LTM can last from a few days to a lifetime. LTM consists of explicit memory (requiring conscious awareness) and implicit memory (unconscious awareness). Information selected for LTM goes through three processes. First, in the encoding stage, information from the senses is incorporated into mental activity in the form of a memory. Secondly, storage involves taking this information and holding it indefinitely in memory. Lastly, retrieval is the ability to recall information from the long term memory storage. Each of these processes can be affected by alcohol.

Explicit Memory
Explicit memory requires conscious and intentional effort for recall. It includes both episodic memory (for everyday events) and semantic memory (for factual information).

Alcohol impairs episodic encoding, specifically for cued recall, recognition of completed word fragments, and free recall. A blackout is an example of a difficulty in encoding episodic memories due to alcohol. Blackouts are caused by a rapid increase in blood alcohol concentration (BAC) which in turn distorts the neurons in the hippocampus. This distortion impairs a person's ability to form new episodic memories.

High doses of alcohol severely disrupts the storage process of semantic memories. Alcohol was found to impair the storage of novel stimuli but not that of previously learned information. Since alcohol affects the central nervous system, it hinders semantic storage functioning by restricting the consolidation of the information from encoding.

Retrieval of explicit memory is significantly impaired by alcohol. When compared to sober participants, intoxicated participants performed quite poorly on a recall task for everyday events (episodic memory). Intoxicated participants are also slower to respond in reaction time tasks. Alcohol also impairs retrieval in word recognition tasks. When both encoding and retrieval take place during intoxication, there are surprisingly more impairments for cued recall than for free recall. In terms of gender differences in retrieval processes, females tend to score lower than males on recall tasks when intoxicated.

Implicit Memory
Implicit memory does not require conscious effort or intention for recall. It occurs when previous experience influences performance on a certain task. This is evident in priming experiments. Implicit memory includes procedural memory, which influences our everyday behaviours, such as riding a bike or tying your shoes. We can perform these abilities without thinking about them, which means procedural memory functions automatically. While retrieval of explicit memory is severely impaired by alcohol, retrieval of implicit memory is not. Intoxicated subjects score higher on recognition tasks (involving implicit memory) than on recall tasks (involving explicit memory).

Short Term Memory
Short-term memory refers to temporary storage of small amounts of information over short delays. Digit span refers to the proposed number of pieces of information (5-9) that can be held in short-term memory. This is also referred to as the magic number seven – plus or minus two. Any more pieces of information than this, and newer items replace previous items. Alcohol intoxication has been found to have dissociative effects on short-term memory and cognitive functioning.

Brain Areas Affected by Alcohol
Alcohol affects brain functioning. Neurochemical changes occurring in the anterior cingulate are correlated with altered short-term memory functions in the brains of young alcoholic men. fMRIs of alcohol-dependent women displayed significantly less blood oxygen in the frontal and parietal regions, especially in the right hemisphere. This is supported by findings of short-term memory impairment by lesions of the parietal lobe and prefrontal cortex. Associations between third ventricular volume and cognitive performance on memory tests have been found in alcoholics. Specifically, increases in third ventricular volume correlate with a decline in memory performance.

Tasks and Intoxication Findings
Short-term memory is commonly tested with visual tasks. Short-term memory, especially for non-verbal and spatial material, are impaired by intoxication. Alcohol decreases iconic memory (a type of visual short-term memory). With BACs between 80-84 mg/dl, more intrusion errors occur in a delayed recall task compared to a control group. Intrusion errors, which represent reflective cognitive functioning, occur when irrelevant information is produced. Alcoholics have less control of inhibiting intrusions. Acute alcohol intoxication in social drinkers caused more intrusion errors in delayed recall tasks than in immediate free recall tasks. Acute alcohol intoxication increases susceptibility to interference, which allows for more intrusion errors when there is a short delay. Free recall (given list of words then asked to recall list) is significantly lower and therefore impaired by alcohol intoxication. Encoding deficits were found in verbal free recall and recognition tasks under the influence of alcohol. A discrimination task found significant alcohol-related impairments in depth perception and in visual short-term memory. State-dependent learning and relearning studies in male heavy drinkers demonstrate that the condition of intoxication while learning and sobriety when tested caused a performance deficit in free recall tasks. These findings are supportive of alcohol-induced storage deficits (not retrieval deficits). The effects of acute alcohol consumption on visual short-term memory, stereoscopic depth perception, and attention were studied. A 33% alcohol condition showed significant impairments in depth perception and in visual short-term memory (assessed by the vernier discrimination task).



Working Memory
Working memory involves a system for the temporary storage and manipulation of information, forming a crucial link between perception and controlled action. Evidence suggests a three-component model, comprising an attentional control system, the central executive, and two subsidiary slave systems. One of these,the visuo-spatial sketchpad, holds and manipulates spatial information, while the other, the phonological loop performs a similar function for auditory and speech-based information. Simply, working memory allows one to keep things in mind while simultaneously performing complex tasks.

Immediate Effects and Alcohol Consumption
The measurable effects alcohol consumption has on working memory are as substantial as they are surprising. It is noted that individual response levels to alcohol vastly vary and that little is known about the neural mechanisms that underlie individual differences in levels of response to alcohol. . It is also noted that alcohol impares working memory by affecting certain mnemonic strategies and executive processes rather than by shrinking the basic holding capacity of working memory (or profoundly physically altering the structre of the frontal cortex, parietal cortex, anterior cingulate, and parts of the basal ganglia which are critical for working memory function), with isolated acute-moderate levels of alcohol intoxication. One finding regarding the effects of alcohol on working memory points out that alcohol reduces working memory only in individuals with a high baseline working memory capacity. , suggesting a universal suffering of working memory functionality is non-existent. Alcohol appears to impair the capacity of working memory to modulate response inhibition. Alcohol disinhibits behaviour, but only in individuals with a low baseline working memory capacity. An interesting finding is that incentive to perform well with working memory measurment tasks while under the influence of alcohol does in fact have some effect on working memory, in that it boosts scores in rate of mental scanning and reaction time to stimulus, but did not reduce number of errors compaired to subjects with no incentive to perform well. Even acute alcohol intoxication (a blood alcohol concentration of 0.08-0.09%) produces a substantial impairment of working memory processes that require mnemonic rehearsal strategies. Alcohol is less likely to impair a working memory task that does not rely on memory rehearsal or associated mnemonic strategies. Because of this, working memory is very susceptible to falter when a person is participating in tasks invovling retention concerning auditory and visual 'sequences'. A real world and interesting example of this is failure of guitarists or other musicians performing concertes to que in on auditory patterns and make it known that their performance is hindered by intoxication, where as professional basketball (a less sequence heavy activity for working memory) standout Ron Artest recently admitted in an interview with SportingNews to drinking heavily during half-time of games in the early days of his career and it having little if any recognizable effect on his working memory as his former coach Fran Fraschilla has gone on record saying: "It's a surprise because every day at practice, he came out in a mood to play. He came out in a basketball rage. He was fully committed; he wanted to let our upperclassmen know that he was the alpha male. It never came up that he had any sort of a problem with alcohol. This is the first I've heard of it."

Alcohol's Lasting Effect on Working Memory
Alcohol has shown to have some long term effect on working memory. Findings have shown that for working memory to be substantially affected long-term, heavy drinking must be sustained over a long period of time as up to one drink per day does not impair cognitive function and may actually decrease the risk of cognitive decline. Furthermore, chronic alcoholism is associated with impairment in sustained attention and visual working memory. Thus, alcoholics have reduced ability, but not necessarily inability, to perform these executive tasks, assumed to be subserved by regions of prefrontal cortex. While it may not serve as a surprise that chronic alcoholism has been linked to decreased congnitive function including working memory, one surprising finding is not only that even moderate levels of alcohol consumption during pregnancy were shown to have an adverse affect on the child's working memory when tested at 7.5 years of age, but that working memory may be the most important aspect of attention that is adversely affected by prenatal alcohol exposure. .

Prospective Memory
Alcohol has been found to impair prospective memory. Prospective memory refers to remembering to carry out an intended action in the future without an explicit reminder. Chronic heavy alcohol users report significantly more prospective forgetting compared to low-dose and alcohol-free controls. The Prospective Memory Questionnaire assesses short-term habitual prospective memory, long-term episodic prospective memory, and internally cued prospective memory. Chronic heavy alcohol users reported significantly greater deficits for all three aspects of prospective memory. Individuals that report heavy alcohol use report 23.68% more difficulties with prospective memory than those who report that they are light drinkers and 30% more difficulties than those who report that they never drink. The effects of alcohol on prospective memory can also be assessed in the laboratory by simulating prospective memory tasks that individuals face in everyday life. Individuals who are given 0.6 g/kg alcohol prior to performing prospective memory tasks do significantly poorer than a placebo group. Alcohol can damage the prefrontal and frontal areas of the brain, and this may be responsible for prospective memory impairments since prospective memory performance is highly correlated with frontal executive functions.

In Popular Culture
The memory inhibiting effects of alcohol are often a prominent topic in popular culture. It appears in movies, books, and television shows. Several movies exists with the characters drinking alcohol to the point of memory loss and awakening the next morning with a host of problems due to actions they performed while intoxicated. A recent movie is The Hangover. Three groomsmen lose the groom during a bachelor party in Las Vegas, so they retrace their steps to find him. The characters still had functioning implicit/procedural memory, which allowed them to carry out the many acts they performed that night, but their episodic memory was impaired and thus they had no recollection of the events occurring.

Another movie is What Happens in Vegas. After an intoxicated night in “Sin City,” two people wake-up to find they got married.

Songs such as Waking Up in Vegas by Katy Perry and Last Name by Carrie Underwood also depict characters waking up and not remembering the night before due to alcohol consumption.

Our culture has been infiltraited by light-hearted images and perceptions of memory loss or decline at the hands of alcohol consumption, but there are also more searious dimensions of alcohol consumption and memory that come into the limelight. The most namely being in legal issues in terms of memory loss due to alcohol consumption as a defense. R. v. Daviault [1994], is amongst many poignant cases where alcohol's effect on memory has been the crux of a much publicized trial in Canada.