Wikipedia:USEP/Courses/JHU MolBio Ogg SP14/Group 81D

23S ribosomal RNA
While the article is classified as larger than a stub it still needs a lot of work. . Besides the brevity of the article, it is well written for a technical science article. There are no noticeable spelling or grammar errors. There is one comment in the talk section of this article in which a user requests that the article be rewritten by someone who speaks English as their native language. After re-reading the article it did seem to lack a solid flow, but the same can be said of most scholarly journal articles. Of the three pictures, two of them are from pub med articles and are properly cited. The third picture coincides with a table that comes from the Wikimedia Commons. Both sources used in this one paragraph article come from peer reviewed articles located on pub med. The article is neutral in nature and narrow in its focus. It is missing a citation for the only paragraph which is pointed out either by the user who wrote the article or by a fellow Wikipedian.

References to be used for 23S ribosomal RNA article
1. Analysis of Mutations in the 23S rRNA.

2. Role of precursor sequences in the ordered maturation of E. coli 23S ribosomal RNA.

3. Secondary structure and domain architecture of the 23S and 5S rRNAs.

Bacteriolysis
The Bacteriolysis page is non existent. The talk page is also empty. There is no way to evaluate an empty article page.

References to be used with Bacteriolysis article
1. Intracellular bacteriolysis triggers a massive apoptotic cell death in Shigella-infected epithelial cells.

2. The role of bacteriolysis in the pathophysiology of inflammation, infection and post-infectious sequelae.

3. Bacteriolysis.

Nondisjunction

 *  Well written: The article is currently very short; however, still somewhat unstructured and confusing.
 *  Compliance with layout style, presence of required sections:: The article has only one section, and is not properly divided into subsections.
 *  List of references, and inline citations from verifiable sources: There is only one global reference, but no proper inline citations at all.
 *  Broad coverage, addresses main aspects of the topic: Reasons and mechanisms of nondisjunction are not detailed. Medical aspects are treated much to shortly.
 *  Illustrations: There is only one infobox with a tiny illustration. The illustration lacks clarity and does not properly highlight the central aspect of the process.

Selected literature for topic "Nondisjunction"

 * "Etiology of nondisjunction in humans"
 * "Nondisjunction in trisomy 21: origin and mechanisms"
 * "A review of trisomy X (47,XXX)"
 * "Chromosome segregation and genomic stability"
 * "Origin and mechanisms of non-disjunction in human autosomal trisomies"

Viral transformation (already claimed by other group)

 *  Well written: The article is currently very short; the text is not well structured and mainly lists some facts without putting them into context.
 *  Compliance with layout style, presence of required sections:: The article has two sections, and is not properly divided into subsections. The distinction between the two conceots "virus-induced malignant transformation" and "transformation techniques using viral vectors" should be more elaborated.
 *  List of references, and inline citations from verifiable sources: The article has no reference or inline citations at all.
 *  Broad coverage, addresses main aspects of the topic: Molecular mechanisms are not explained in detail. Medical aspects of virus-induced malignancies are missing. The section on viral transfection vectors consist of only one sentence.
 *  Illustrations: Illustrations are missing completely, but urgently needed.

Selected literature for topic "Viral transformation"

 * "HIV, EBV and KSHV: viral cooperation in the pathogenesis of human malignancies"
 * "The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53"
 * "Viral hit and run-oncogenesis: genetic and epigenetic scenarios"
 * "Novel mechanisms of EBV-induced oncogenesis"
 * "Viral vectors: a look back and ahead on gene transfer technology"
 * "Gene delivery with viral vectors for cerebrovascular diseases"
 * "Viral vectors for gene transfer: a review of their use in the treatment of human diseases"
 * "Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer"

Article selection rationale
The decision in favor of the topic "Nondisjunction" was influenced by the following considerations:
 * The current Wikipedia article on nondisjunction is classified as a stub. The relevance of the topic is underlined by the fact that both the "WikiProject Genetics" and the "WikiProject Molecular and Cellular Biology" rate this article as "high-importance".
 * This topic seems interesting because it combines molecular genetics with medicine. In addition to describing molecular mechanisms, we could exemplify consequences of nondisjunction with human diseases. Nondisjunction is, for example, causative for Down syndrome, Turner syndrome, and Triple X syndrome, among others.
 * It is expected that "Nondisjunction" is a topic that is also searched for by people who are not experts or professionals in the fields of genetics or biology: Medical conditions related to nondisjunction are common enough that patients of relatives of affected persons will be searching for background information on disease mechanisms. The broader range of expected audience has to be reflected by the structure and writing style of the article: starting with a general and easy to understand explanation of the topic, supported by images and examples, before diving into more specialized, academic aspects.
 * Although mechanistic details of nondisjunctions may be quite complicated, the main point of improper chromosome segregation can be nicely visualized. We plan to add animation(s) to the article page showing step-by-step visualization of proper versus defective chromosome movements in meiosis and mitosis.
 * We have several illustrations which we would like to get permission to use; animation 1, animation 2, animation 3, and video 1.

Unit 8 Progress Report

 * ''' All our contributions were prose

Unit 10 Progress Report

 * ''' All our contributions were prose


 * Several reviewer suggestions were used to improve structure, formatting and readability of the article.
 * A dedicated lead section was added according to the Wikipedia style guideline.
 * Additional content was added, mainly in sections "Consequences of nondisjunction", "Diagnosis" and in the lead section.

Unit 12 Progress Report

 * Added illustration "mitotic nondisjunction"
 * Resized and repositioned illustrations and text sections
 * Re-organized and extended section "consequences of nondisjunction"

Final progress report

 * Added illustration "Trisomy resulting from nondisjunction in maternal meiosis I"
 * Added illustration "Malignant transformation according to the two-hit model"
 * Added illustration "Karyotype of X monosomy (Turner syndrome)"
 * Added illustration "Karyotype of trisomy 21 (Down syndrome)"
 * Extended information in sub-sections "meiosis II" and "mitosis" of section "Types"
 * Several corrections of typos and wikilinks
 * Restructuring of section "Molecular mechanisms", addition of three subsections