Wikipedia talk:USEP/Courses/JHU MolBio Ogg SP14/Group 81D

Article selection
For moving the process of article selection for our group forward, I will try to summarize our current position:


 * Viral transformation: This topic has already be claimed by group H.
 * Bacteriolysis: This seems to be an older term that is only rarely used in current literature. I did not find a review on this topic published in the last 5 years.
 * 23S ribosomal RNA: This seems to be an interesting topic with useful and up-to-date literature available. The current Wikipedia article has two good images on 3 dimensional structure. We would need additional images showing the positions of the 23S unit in the ribosome. There will possibly be some overlap with articles "Ribosomal RNA" and Rimbosome. I think we should consider working on article "Ribosomal RNA" instead: This article is also incomplete, currently rated as "start class" and "high priority".
 * Nondisjunction: This topic seems also interesting because it combines molecular genetics with medicine. In addition to describing molecular mechanisms, we could exemplify consequences of nondisjunction with human diseases. We would need a good schematic diagram depicting the molecular mechanisms. If we find some we could also add histologic images of a malformed mitotic spindle. Up-to-date literature on the topic seems to be available.

Wpeissner (talk) 21:46, 4 March 2014 (UTC)

The ability to embed animation into our article would be useful. Something similar to this. Another good video idea from Youtube. Previte01 (talk) 02:15, 5 March 2014 (UTC)

Adding animations is a great idea. We should really do this! Some Wikipedia articles use animated GIF images for displaying the animation directly on the article page. Take a look at the article for the computer science topic Merge sort. Wpeissner (talk) 02:21, 5 March 2014 (UTC)

Article discussion
Hey Wpeissner. I am going to begin to list key items that we should discuss in our article. Feel free to add/edit at your convenience.

Lead Section
1. Our lead section will define nondisjunction. The current article defines nondisjunction as "the failure of chromosome pairs to separate properly during meiosis stage 1 or stage 2, specifically in the anaphase." We could choose to keep this definition or improve upon it from our sources/references.

2. We will also establish context as to why nondisjunction is important. We will need to elaborate on why it is harmful and what it can do as a result of its existence. The current article states, "In the event that an aneuploidic gamete is fertilized, a number of syndromes might result. The only known survivable monosomy is Turner syndrome, where the individual is monosomic for the X chromosome. Examples of trisomies include Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), and Patau syndrome (trisomy 13)." We can research any other known effects of nondisjunction and perhaps give a little more information on the molecular/cellular effects.

Illustrations
1. One thing we both agree on is that a portion of this article will have images, animations, and or videos of nondisjunction. We will come together as a team to select the best illustrations to help support our article.

2. We can compile a list of possible illustrations and add them to the sandbox of choice. We already have a few listed above.

History
1. I've noticed that a lot of good articles on Wikipedia begin with a history. We should see what kind of references we can find on who discovered nondisjunction, when they discovered it, etc.

2. Were there any awards or notable research associated with this discovery? We can probably keep this section relatively short. Maybe 3-4 sentences at best.

Signs and Symptoms
1. Can we find out physical and molecular signs of of nondisjunction?

Causes
1. If there are multiple causes, we could give it its own section.

Diagnosis
1. How is it diagnosed?

2. Has the way its been diagnosed changed over time with an increase in technology?

3. What tests, machines, techniques are used to diagnose nondisjunction?

Prevention
1. Is there anyway to prevent nondisjunction?

Treatment
1. I have a feeling this may be an non-treatable issues but we could still look into this and give it its own section if warranted.

Research
1. Any current or past research could go here