Wikipedia talk:WikiProject Molecular Biology

Requested move at Talk:3α-Hydroxysteroid dehydrogenase
There is a requested move discussion at Talk:3α-Hydroxysteroid dehydrogenase that may be of interest to members of this WikiProject. Natg 19 (talk) 23:23, 18 April 2024 (UTC)


 * See Talk:AKR1C4 for closed discussion with outcome of 'Move'. --User:Ceyockey ( talk to me ) 03:38, 16 July 2024 (UTC)

MID gene
Just a quick question is there any articles about a gene in particular? I’m talking about a gene called MID (minus dominance). There does seem to be a lot of sources about this gene from:

[https://www.nature.com/articles/s42003-022-04275-y#:~:text=The%20mating%20type%20of%20C,to%20mt%2B%20in%20its%20absence. here]

here

here

Just asking to make sure it doesn’t go by a different name or something. I’m also wondering if genes here on Wikipedia have a certain style or policies.

Also I am bringing this up to see what y’all think about there being an article on this gene. When researching the evolution of sexes and mating types I noticed a lot of sources keep mentioning this gene.CycoMa1 (talk) 04:52, 2 May 2024 (UTC)


 * Wikipedia is a popular encyclopedia intended for a diverse audience. There are 25,000 genes in the human genome and something close to one million different different genes in the biosphere. We do not need to have a separate Wikipedia article for each gene.
 * But there's another problem that just as important. Any article on an individual genes is certainly going to bring up the definition of a gene and important issues such as regulation, evolution, and alternative splicing. It is proving to be very difficult to get individual editors to stick to the definitions and descriptions of these features that have been thrashed out in the articles specific to those topics. This leads to a lot of confusion and conflict so we should be very cautious about creating any new molecular biology articles unless they are absolutely necessary. Genome42 (talk) 14:57, 2 May 2024 (UTC)
 * Does your response suggest that the "Gene Wiki Project" has been abandoned? --User:Ceyockey ( talk to me ) 03:43, 16 July 2024 (UTC)

Mitochondrial fatty acid synthesis in lipid-related articles
Hello.

Mitochondrial fatty acid synthesis (mtFASII) is not yet well incorporated into the lipid-related articles or is completely missing in some of them. Therefore I ask for your help.

Could someone revise the introductory section of fatty acid synthesis? It should be clearer and earlier in the text that there are 2 different fatty acid syntheses in humans, cytosolic fatty acid synthesis (FASI) and mitochondrial fatty acid synthesis (mtFASII). The other sections of the article are also not quite coherent, you can simply see that the article was written with the knowledge that fatty acid synthesis only takes place in the cytosol.

In the articles on fatty acid and lipid metabolism, mitochondrial fatty acid synthesis is completely missing. Abvdj (talk) 12:45, 19 May 2024 (UTC)

Regarding fatty acyl-CoA esters
Hey there! I've been working on adding sources to the article fatty acyl-CoA esters, but since I haven't much expertise in the subject area, I'd like to get some clarification -- in particular, what's the relation between these esters and acyl-CoA itself? It seems the same process of beta-synthesis in mitochondrial metabolism is described in each. Thanks! DeemDeem52 (talk) 16:09, 28 May 2024 (UTC)


 * My impression is that they are the same thing, with Fatty acyl-CoA esters having a much more confusing name. Jo-Jo Eumerus (talk) 07:09, 29 May 2024 (UTC)
 * Hmm... if that's the case, then perhaps the page should be merged. I'll put in a merge proposal and see if it can't get consensus. Thanks! DeemDeem52 (talk) 14:53, 29 May 2024 (UTC)

Requested move at Talk:Ketone bodies
There is a requested move discussion at Talk:Ketone bodies that may be of interest to members of this WikiProject. Safari Scribe Edits! Talk! 00:15, 2 June 2024 (UTC)


 * The outcome of this request was "Not moved". --User:Ceyockey ( talk to me ) 03:45, 16 July 2024 (UTC)

Source evaluation requested at Promoter (genetics)
Over at WikiProject Mathematics, we ran into a citation-spamming issue, where references to a substandard book were inserted by a COI editor. The statements being spammed with these citations were, variously, summaries that didn't need to be cluttered with footnotes, already supported by other references, or not actually supported by the spam reference. The article Promoter (genetics) may also have been affected. It would greatly help if a subject-matter specialist could evaluate the two sources (cited a total of seven times between them) co-authored by P. Gagniuc. Are the claims accurate and worth the words spent on them? Should the statements in question be cited to textbooks instead? XOR&#39;easter (talk) 23:14, 14 June 2024 (UTC)

Looking for some opinions
Please see External links/Noticeboard. We are looking for opinions about whether some ==External links== would be valuable. WhatamIdoing (talk) 03:32, 19 June 2024 (UTC)

UK Biobank
Hi everybody. I have been hired by UK Biobank to improve the article. I have uploaded an edit request on the talk page which I think would benefit from some specialist knowledge as some of the updates relate to concepts within the scope of this project and COMPBIO. Any help or feedback would be appreciated! Burchrusks (talk) 10:50, 19 June 2024 (UTC)

ETS2
I've added a bit to the ETS2 article to reflect the latest paper in Nature linking ETS2 with a wide range of inflammatory diseases. Please amend, or even remove, this if what I've written is wrong. &mdash; The Anome (talk) 20:59, 22 June 2024 (UTC)


 * ETS2 is a fairly important transcription factor, and these often have multiple functions. I think this addition is WP:UNDUE as it emphasizes one function among many, but mostly b/c the article currently doesn't list any other function so I am not sure if it should be removed. Typical problem with well-studied proteins, really. Jo-Jo Eumerus (talk) 17:27, 23 June 2024 (UTC)


 * Do we really need to have separate Wikipedia articles for every human gene? I don't think so.


 * Is it a good idea to insert all the latest speculations about the function of a given gene before they are confirmed by additional experiments in other labs? I don't think so. Genome42 (talk) 19:54, 23 June 2024 (UTC)

RetractionBot
I posted this story from the Signpost last month. Things have evolved a bit and now Retraction bot handles Erratum, Expression of concern, and Retracted. These populate the following categories:


 * Category:Articles citing retracted publications

• #Adrenaline

• #He Jiankui affair

• #Akt/PKB signaling pathway

• #AKT2

• #Albumin transport function analysis by EPR spectroscopy

• #Alveolar macrophage

• #ANGPTL8

• #Antiglucocorticoid

• #Apoptosis

• #Antonio Arnaiz-Villena

• #Arsenic biochemistry

• #ABC transporter

• #Autoimmune disease

• #Axon guidance

• #BCAS3

• #Biotechnology

• #C9orf3

• #Calcium signaling in cell division

• #Cardiac muscle

• #Cathelicidin antimicrobial peptide

• #CEBPB

• #Chorionic villus sampling

• #CHUK

• #Class A basic helix-loop-helix protein 15

• #Collagen, type IV, alpha 1

• #Cyclin-dependent kinase 2

• #De novo gene birth

• #Netrin receptor DCC

• #DNA ligase 3

• #DSCAM

• #Early prostate cancer antigen-2

• #Garth Ehrlich

• #EP300

• #Epigenetics

• #FAM162A

• #Florigen

• #Free fatty acid receptor 4

• #Galectin-9

• #Gasotransmitter

• #Gene-for-gene relationship

• #Genetically modified organism

• #GPR132

• #H+, Na+-translocating pyrophosphatase family

• #HEPN1

• #HHV Latency Associated Transcript

• #HYAL1

• #Hypoxia-inducible factor

• #IFI16

• #Inorganic pyrophosphatase

• #Large tumor antigen

• #Let-7 microRNA precursor

• #List of phylogenetics software

• #Long non-coding RNA

• #LOXL2

• #Lymphocyte expansion molecule

• #MED12

• #MED24

• #Mesenchymal stem cell

• #MicroRNA

• #Migration-inducting gene 7

• #Mir-31

• #Mir-133 microRNA precursor family

• #Mir-192/215 microRNA precursor

• #MiR-203

• #Mir-802 microRNA precursor family

• #Msh homeobox 2

• #MTDH

• #Neurogenins

• #Non-coding RNA

• #Non-mevalonate pathway

• #Nuclear receptor coactivator 1

• #Nuclear receptor coactivator 2

• #Nuclear receptor coactivator 3

• #Nuclear receptor coregulators

• #Paracrine signaling

• #Pericyte

• #PHLPP

• #Poly(3-hydroxybutyrate) depolymerase

• #Prostaglandin EP1 receptor

• #Protein inhibitor of activated STAT

• #RAP1B

• #Regeneration in humans

• #Reprimo

• #Ribonuclease L

• #RNA interference

• #ROCK1

• #Séralini affair

• #SKP2

• #Slit-Robo

• #SMARCC2

• #Somatostatin receptor 2

• #Sphingosine kinase 1

• #SRA1

• #Stem cell

• #Steroidogenic acute regulatory protein

• #STK3

• #Subtelomere

• #SUCNR1

• #SUPT16H

• #TIMD4

• #TP53-inducible glycolysis and apoptosis regulator

• #Transformation/transcription domain-associated protein

• #TSC2

• #TSG101

• #Unconventional myosin-Va


 * Category:Articles citing publications with expressions of concern

• #Cln3

• #COVID-19 testing

• #Culturomics (microbiology)

• #CXCL9

• #DNA repair

• #Hepatocyte growth factor

• #HSPA1B

• #Human genetic enhancement

• #Human germline engineering

• #Inositol

• #Interleukin 40

• #MicroRNA

• #Morpholino

• #Nodal signaling pathway

• #Regeneration (biology)

• #Restriction point

• #TAR DNA-binding protein 43

• #TAS2R46

• #Vitamin K2


 * Category:Articles citing publications with errata

• #David Baulcombe

• #Causes of cancer

• #Epigenetic clock

• #MiR-203

• #RNA activation

• #Rubicon (protein)

• #SNARE protein

• #Variants of SARS-CoV-2

If the citation is no longer reliable, then the article needs to be updated, which could be as minor as the removal/replacement of the citation with a reliable one, to rewriting an entire section that was based on flawed premises. If the citation to a retracted paper was intentional, like in the context of a controversy noting that a paper was later retracted, you can replace with / with / with.

I put the list of articles within the scope of WP:MCB in collapsed sections. Any help you can give with those are greatly appreciated. Feel free to remove/strike through those you've dealt with. &#32; Headbomb {t · c · p · b} 20:27, 15 July 2024 (UTC)


 * This is great. Thank you.  I've always wondered how we deal with retracted articles and now you've presented at least some alerting automation.  --User:Ceyockey ( talk to me ) 03:48, 16 July 2024 (UTC)