William Appleton

William Appleton may refer to:


 * William Appleton (politician) (1786–1862), congressman from Massachusetts
 * Will Appleton (1889–1958), mayor of Wellington, New Zealand
 * W. A. Appleton (William Archibald Appleton, 1859–1940), British trade union leader
 * William Sumner Appleton (1874–1947), founder of the Society for the Preservation of New England Antiquities
 * William M. Appleton (1920–2001), Pennsylvania politician
 * William Henry Appleton (1814–1899), American publisher
 * William Appleton (entrepreneur) (born 1961), American entrepreneur and technologist
 * William H. Appleton (1843–1912), American soldier and Medal of Honor recipient
 * William Thomas Appleton (1859–1930), Australian businessman, shipping agent and public servant