William Bruce

William Bruce may refer to:
 * Sir William Bruce (architect) (c. 1630–1710), Scottish architect
 * William Bruce, 8th Earl of Kincardine (died 1740), Scottish nobleman
 * William Bruce (cricketer) (1864–1925), Australian cricketer
 * William Bruce (Canadian politician) (died 1838), physician and politician in Upper Canada
 * William Bruce (VC) (1890–1914), posthumous recipient of the Victoria Cross
 * William Cabell Bruce (1860–1946), author and United States Senator
 * Major William Bruce-Gardyne of Clan Gardyne, Laird of Middleton, Angus, Scotland
 * William Speirs Bruce (1867–1921), Scottish explorer
 * William George Bruce (1856–1949), Milwaukee publisher, historian, and civic leader
 * William Bruce (minister, born 1757) (1757–1841), Irish Presbyterian and educator
 * William Bruce (minister, born 1790) (1790–1868), Irish Presbyterian and professor
 * William Blair Bruce (1859–1906), Canadian painter
 * William Napier Bruce (1858–1936), British educationalist and lawyer
 * William J. Bruce III, American author and publicist