William Cocke (disambiguation)

William Cocke (1748–1828) was an American pioneer, state legislator, and U.S. senator.

William Cocke may also refer to:


 * W. A. Cocke (1796–1844), mayor of Louisville, Kentucky
 * William Michael Cocke (1815–1896), member of the U.S. House of Representatives from Tennessee
 * William A. Cocke (1822–1887), Florida Attorney General, 1873–1876
 * William Cocke (1672–1720) (1672 - 1720) was a prominent Virginia politician in the 1710s and as Alexander Spotswood's personal physician, was one of the first university-trained doctors in Virginia.