William Duke

William Duke may refer to:


 * William Duke (civil servant) (1863–1924), governor of Bengal
 * William Duke (artist) (1814–1853), Irish-born Australian artist
 * William Duke (mathematician) (born 1958), American mathematician
 * William B. Duke (1857–1926), American Hall of Fame racehorse trainer
 * William Mark Duke (1879–1971), Canadian archbishop