William Guthrie

William Guthrie may refer to:
 * William Guthrie (boxer) (born 1967), American boxer
 * William Guthrie (historian) (1708–1770), Scottish writer and journalist
 * William Guthrie (politician) (1884–1954), Canadian politician
 * William Guthrie (minister) (1620–1665), Scottish Presbyterian minister and author
 * William Dameron Guthrie (1859–1935), American lawyer
 * W. K. C. Guthrie (William Keith Chambers Guthrie, 1906–1981), Scottish classical scholar and philosophy professor
 * William Norman Guthrie (1868–1944), American clergyman
 * William Tyrone Guthrie (1900–1971), English theatre director