William Hume

William Hume may refer to:
 * Bill Hume (footballer) (1937–2005), English-born soccer player who played for New Zealand and Australia
 * Bill Hume (cartoonist) (1916–2009), American artist, art director, and newspaper man
 * Billy Hume (1935–1990), Scottish footballer
 * Willie Hume (1862–1941), cyclist, first ever winner on Dunlop pneumatic tyres
 * William Hume (Cape politician) (1837–1916), politician of the Cape Colony
 * William Errington Hume (1879–1960), English physician (knighted in 1952)
 * William H. Hume, American architect in New York City
 * William J. Hume, American heir, businessman and conservative philanthropist
 * William Fraser Hume (1867–1949), British geologist