William Jefferson

William Jefferson may refer to:


 * William Jefferson (actor) (1876–1946), American stage and film actor
 * William J. Jefferson (born 1947), former Louisiana Democratic congressman
 * Will Jefferson (born 1979), English cricketer
 * William Jefferson (United Nations employee) (1951–1995), killed serving in Bosnia in the 1990s
 * Bill Jefferson (baseball) (1904–1976), American baseball pitcher