William Jeffrey

William or Bill Jeffrey may refer to:
 * Bill Jeffrey (born 1948), British civil servant
 * William A. Jeffrey, American scientist
 * William Jeffrey (cricketer) (1950–1993), Guyanese cricket player and coach
 * William Jeffrey (footballer) (1866–1932), English footballer with Burnley, Arsenal and Southampton
 * William Jeffrey (American soccer) (1892–1966), head coach of the 1950 United States World Cup team
 * William Jeffrey (Tsimshian chief) (born 1899), hereditary Tsimshian Chief, First Nations activist and carver
 * William Jeffrey, a pseudonym of writer Bill Pronzini