William Locke

William Locke may refer to:


 * William Locke of Norbury 18th-century English patron of the arts, see Joseph Wilton
 * William Henry Locke, chaplain and writer during the American Civil War
 * William Locke (general) (1894–1962), officer in the Australian Army
 * William John Locke (1863–1930), English novelist, born in British Guyana of English parents
 * William Locke (baseball), owner of the Philadelphia Phillies in 1913 on List of Philadelphia Phillies owners and executives