William Mathews

William Mathews may refer to:


 * William Mathews (cricketer) (1793–1858), English cricketer
 * William A. Mathews (1800–1856), Texas colonist, soldier, courier and quartermaster in the Texas Revolution
 * William Mathews (mountaineer) (1828–1901), English mountaineer and botanist
 * William Gordon Mathews (1877–1923), federal judge and lawyer in West Virginia
 * William Shirley Mathews (1848–1915, Osage Nation politician
 * Bill Mathews (William Henry Mathews, 1919–2003), Canadian geologist