William Nichols

William or Bill Nichols may refer to:
 * William Nichols (English priest), Dean of Chester, 1644–1657
 * William Nichols, secretary of John Fell, 17th century clergyman
 * William Nichols (mariner) (fl. 1758–1780), English sea captain
 * William Nichols (architect) (1780–1853), English-born American architect
 * William T. Nichols (1829–1882), American politician, soldier, and businessman
 * William Nichols (Medal of Honor) (1837–?), American Civil War sailor and Medal of Honor recipient
 * William Ripley Nichols (1847–1886), American chemist and leading authority on water purification
 * William Ford Nichols (1849–1924), Bishop of California in the Episcopal Church
 * William Francis Nichols (1852–1917), American businessman and politician
 * William H. Nichols (1852–1930), American chemist and businessman
 * William Nichols, founder of Nichols School, Buffalo, New York, in 1892
 * Bill Nichols (politician) (1918–1988), United States Representative from Alabama
 * Billy Nichols (born 1940), American musician
 * Bill Nichols (film critic) (born 1942), American historian and film theorist
 * William Nichols (artist) (born 1942), American artist