William Nye

William Nye may refer to:


 * Bill Nye (William Sanford Nye, born 1955), American science educator, comedian, television host and mechanical engineer
 * Will Nye, American television actor in Murder, She Wrote 1988–1991
 * William Foster Nye (1824–1910), businessman who founded Nye Lubricants in 1844
 * William B. Nye, former member of the 107th and 108th Ohio General Assembly 1967–1970
 * William M. Nye (1829–1905), member of the Wisconsin State Assembly
 * William Nye (official) (born 1966), Secretary-General of the Archbishops' Council
 * William Nigh (1881–1955), American filmmaker, sometimes credited as "William Nye"