William Poole (disambiguation)

William Poole (1821–1855), also known as "Bill the Butcher", was an American gang member and leader of the Know Nothing political movement

William Poole may also refer to:
 * William Poole (Australian politician) (1828–1902), New South Wales politician
 * William Poole (economist) (born 1937), American economist, former president of the Federal Reserve Bank of St. Louis
 * William A. Poole (1831–1903), merchant and politician from Prince Edward Island, Canada
 * William B. Poole (1833–1904), American sailor and Medal of Honor recipient
 * William Frederick Poole (1821–1894), American bibliographer and librarian
 * William H. Poole (politician), member of the California legislature
 * William H. Poole (writer) (1820–1896), Canadian minister and writer
 * William Henry Poole (1876–1921), college football player and minister
 * William Henry Evered Poole (1902–1969), South African military commander and diplomat
 * William Leslie Poole (1866–1931), English immigrant to Uruguay important to the development of association football in Uruguay
 * William Mansfield Poole (1871–1946), educationalist and author
 * William T. Poole, 20th-century American research analyst for the US Congress