William S. Smith

William S. Smith may refer to:


 * William Stephens Smith (1755–1816), United States Representative from New York
 * Sir William Sidney Smith (Royal Navy officer), British admiral
 * William Saumarez Smith (1836–1909), Australian Anglican archbishop
 * William Sooy Smith (1830–1916), American Civil War general
 * William Sidney Smith (assemblyman), New York politician
 * William S. Smith Jr. (born 1947), former president of the Association of Universities for Research in Astronomy (AURA)