William Spence (disambiguation)

William Spence (1846–1926) was an Australian trade union leader and politician.

William Spence may also refer to:


 * William Spence (burgess), Virginia colonist and member of House of Burgesses
 * William Spence (engineer), engineer and iron founder of the Cork Street Foundry, Dublin
 * William Spence (entomologist) (c. 1783–1860), British economist and entomologist
 * William Spence (mathematician) (1777–1815), Scottish mathematician
 * William Spence (sculptor) (1793-1849), English sculptor based in Liverpool
 * William Spence (MP), MP for Sussex
 * William Spence (architect) (1806–1883), Scottish architect
 * William Blundell Spence (1814–1900), English artist and art dealer
 * William Robert Spence (1875–1954), Scottish trade union leader
 * William Wallace Spence (1815–1915), Baltimore financier
 * William Spence (schoolmaster), 17th-century Scottish schoolmaster imprisoned for teaching Presbyterianism
 * William Spence (footballer), English footballer