William Sprague

William Sprague may refer to:
 * William Sprague (1609–1675), original American settler
 * William Buell Sprague (1795–1876), American clergyman and compiler of Annals of the American Pulpit
 * William Sprague III (1799–1856), American politician from Rhode Island, uncle of William Sprague IV
 * William Sprague (Michigan politician) (1809–1868), politician from Michigan
 * William P. Sprague (1827–1899), politician from Ohio
 * William Sprague IV (1830–1915), politician from Rhode Island, nephew of William Sprague III
 * William George Robert Sprague (1863–1933), London theatre designer
 * William C. Sprague (1860–1922), founder of The American Boy magazine