Wolf Creek (St. Francis River tributary)

Wolf Creek is a stream in eastern St. Francois County in the U.S. state of Missouri. It is a tributary of the St. Francis River.

The stream headwaters arise just northeast of Farmington at 37.79222°N, -90.37194°W at the confluence of Camp Creek and Taylor Branch. The stream flows south passing under Missouri Route 32. It flows southwest to its confluence with the St. Francis at 37.7275°N, -90.40583°W at an elevation of 814 feet.

Wolf Creek was so named due to the presence of wolves in the area.