XVI Venice Challenge Save Cup – Singles

João Domingues was the defending champion but chose not to defend his title.

Gianluigi Quinzi won the title after defeating Gian Marco Moroni 6–2, 6–2 in the final.

Seeds
• # 🇧🇪 Arthur De Greef (first round)

• # 🇷🇸 Danilo Petrović (semifinals)

• # Yang Tsung-hua (first round)

• # 🇮🇹 Gianluigi Quinzi (champion)

• # 🇧🇦 Tomislav Brkić (second round)

• # 🇺🇸 Mitchell Krueger (semifinals)

• # 🇮🇹 Lorenzo Giustino (quarterfinals)

• # 🇪🇸 Carlos Boluda-Purkiss (first round)