YWHAQ

14-3-3 protein theta is a protein that in humans is encoded by the YWHAQ gene.

Function
This gene product belongs to the 14-3-3 family of proteins that mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence that is polymorphic; however, there is no correlation between the repeat number and the disease.

Interactions
YWHAQ has been shown to interact with:


 * BAX,
 * BAD,
 * C-Raf,
 * CRTC2,
 * CBL
 * HDAC5,
 * MEF2D,
 * NRIP1,
 * PFKFB2,
 * PRKD1,
 * PRKCZ,
 * TERT, and
 * UCP3.