Yotsuba

Yotsuba may refer to:
 * Yotsuba&!, a Japanese manga by Kiyohiko Azuma
 * Yotsuba Koiwai, the title character from Yotsuba&!
 * Yotsuba, a character from the manga and anime Sister Princess
 * Yotsuba Nakano, a character from the manga and anime The Quintessential Quintuplets
 * Yotsuba Group, the name of a group in the Japanese manga and anime Death Note