ZC3H11A

Zinc finger CCCH domain-containing protein 11A is a protein that in humans is encoded by the ZC3H11A gene. ZC3H11A is a part of the transcription export (TREX) complex and plays a role in exporting of mRNAs from nucleus to cytoplasm. It is considered as stress-induced nuclear protein and maintains mRNAs exporting when the cells are under stress. Loss of functioning of ZC3H11A gene in HeLa cells results in abortion of the replication of nuclear replicating viruses but not cytoplasmic replicating viruses. It is discovered that ZC3H11A is significant for viability and metabolic regulation of mouse embryo