1-Deoxy-D-xylulose 5-phosphate

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1-Deoxy-d-xylulose 5-phosphate
Names
IUPAC name
(2,3-dihydroxy-4-oxopentyl) dihydrogen phosphate
Other names
DOXP
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
DrugBank
KEGG
MeSH 1-deoxy-D-xylulose+5-phosphate
UNII
  • InChI=1S/C5H11O7P/c1-3(6)5(8)4(7)2-12-13(9,10)11/h4-5,7-8H,2H2,1H3,(H2,9,10,11)/t4-,5-/m1/s1 checkY
    Key: AJPADPZSRRUGHI-RFZPGFLSSA-N checkY
  • InChI=1/C5H11O7P/c1-3(6)5(8)4(7)2-12-13(9,10)11/h4-5,7-8H,2H2,1H3,(H2,9,10,11)/t4-,5-/m1/s1
    Key: AJPADPZSRRUGHI-RFZPGFLSBQ
  • O=P(O)(O)OC[C@@H](O)[C@H](O)C(=O)C
Properties
C5H11O7P
Molar mass 214.11
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

1-Deoxy-d-xylulose 5-phosphate is a biosynthetic intermediate in the non-mevalonate pathway.[1]

Function[edit]

The non-mevalonate pathway intermediate 1-deoxy-d-xylulose 5-phosphate (DXP) acts as a precursor to make isoprenoids in many species such as bacteria, plants, and apicomplexan parasites which contribute to biological diversity.[2] Specifically, the versatility of intermediate DXP as a starting material can be illustrated in other metabolic application such as improving the production of compounds known as sesquiterpenoids utilizing uncommon carbon sources methane 4,7 in specific bacteria.[3]

References[edit]

  1. ^ "1-deoxy-D-xylulose 5-phosphate". PubChem. U.S. National Library of Medicine. Retrieved 2024-05-04.
  2. ^ Bartee D, Freel Meyers CL (October 2018). "Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism". Accounts of Chemical Research. 51 (10): 2546–2555. doi:10.1021/acs.accounts.8b00321. PMC 6309272. PMID 30203647.
  3. ^ Nguyen AD, Pham DN, Chau TH, Lee EY (June 2021). "Enhancing Sesquiterpenoid Production from Methane via Synergy of the Methylerythritol Phosphate Pathway and a Short-Cut Route to 1-Deoxy-D-xylulose 5-Phosphate in Methanotrophic Bacteria". Microorganisms. 9 (6): 1236. doi:10.3390/microorganisms9061236. PMC 8227265. PMID 34200225.

See also[edit]

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