Aminotransferase, class V
| Aminotransferase class-V | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | Aminotran_5 | ||||||||||
| Pfam | PF00266 | ||||||||||
| InterPro | IPR000192 | ||||||||||
| PROSITE | PDOC00514 | ||||||||||
| SCOP2 | 1bjo / SCOPe / SUPFAM | ||||||||||
| CDD | cd00611 | ||||||||||
| |||||||||||
Aminotransferase class-V is an evolutionary conserved protein domain. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Aminotransferases share certain mechanistic features with other pyridoxal- phosphate dependent enzymes, such as the covalent binding of the pyridoxal- phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped[1] into subfamilies. This family is called class-V.
Subfamilies[edit]
- Phosphoserine aminotransferase InterPro: IPR003248
- Cysteine desulfurase InterPro: IPR010240
- Cysteine desulphurase related, unknown function InterPro: IPR010969
- Cysteine desulphurases, SufS InterPro: IPR010970
- Cysteine desulphurase related InterPro: IPR011340
- 2-aminoethylphosphonate—pyruvate transaminase InterPro: IPR012703
Human proteins containing this domain[edit]
AGXT; KYNU; MOCOS; NFS1; PSAT1; SCLY; TLH6;
References[edit]
- ^ Ouzounis C, Sander C (May 1993). "Homology of the NifS family of proteins to a new class of pyridoxal phosphate-dependent enzymes". FEBS Letters. 322 (2): 159–64. Bibcode:1993FEBSL.322..159O. doi:10.1016/0014-5793(93)81559-I. PMID 8482384. S2CID 14587217.
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