Charis Eng

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Charis Eng
Born1962
Singapore
NationalityAmerican
EducationMD, University of Chicago (Chicago, IL); PhD, University of Chicago (Chicago, IL)
OccupationClinical Geneticist
Years active1988-present
EmployerCleveland Clinic Genomic medicine Institute
Known forPTEN, genomic medicine, cancer genetics, autism
AwardsATA Van Meter Award, Ernst Oppenheimer Award of The Endrocrine Society, and American Cancer Society
Websitehttps://www.lerner.ccf.org/gmi/eng/

Charis Eng is a Singapore-born physician-scientist and geneticist at the Cleveland Clinic, notable for identifying the PTEN gene.[1] She is the Chairwoman and founding Director of the Genomic Medicine Institute of the Cleveland Clinic, founding Director and attending clinical cancer geneticist of the institute’s clinical component, the Center for Personalized Genetic Healthcare, and Professor and Vice Chairwoman of the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine.

Education[edit]

Eng was born in Singapore in the year 1962 and grew up in Bristol, England. She graduated from the University of Chicago Laboratory Schools and matriculated in the University of Chicago at age 16.[1] She earned her Ph.D. in Developmental Biology in 1986 and her M.D. in 1988, both from the Pritzker School of Medicine, University of Chicago. Afterwards, she specialized in internal medicine at Beth Israel Hospital, Boston and trained in medical oncology at Harvard’s Dana-Farber Cancer Institute. She was formally trained in clinical cancer genetics at the University of Cambridge and the Royal Marsden NHS Trust, UK, and in laboratory-based human cancer genetics by Prof Sir Bruce Ponder. Following her training, Eng became one of only four formally-trained clinical cancer geneticists in the US.

Career[edit]

Eng returned to the Farber as Assistant Professor of Medicine at the end of 1995, and in January 1999 joined The Ohio State University as Associate Professor of Medicine and Director of the Clinical Cancer Genetics Program. In 2001, she was appointed to the Davis Professorship and Co-Director of the Division of Human Genetics in the Department of Internal Medicine. In 2002, she was promoted to Professor and Division Director, holding the Klotz Endowed Chair.[1][2]

Eng joined the Cleveland Clinic in 2005,[3] and became the founding director of the Cleveland Clinic's Genomic Medicine Institute and the Center for Personalized Genetic Healthcare, and Professor and Vice Chair of the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine.[4]

Outside of the lab, Eng acted as the primary genetics consultant to the Discovery Health Channel documentary "Curse of the Elephant Man", which traced the genetic causes of Joseph Merrick's disfiguring disorder.[5][6]

Research[edit]

Eng’s research has been acknowledged as the paradigm for performing cancer genetics research which can be brought to clinical practice. At the clinical interface, she is acknowledged as one of the rare “go to” people on what is and how to implement genetic- and genomics-enabled personalized healthcare. She was the first to discover a link between mutations in the cancer suppressor gene PTEN and Cowden and other syndromes, which predispose patients to several types of cancer.[4][7][8]

Her scientific accomplishments have set the practice model for how to apply laboratory-based genetics and genomics in the pre-symptomatic diagnosis, counseling and management of patients and their as-yet unaffected family members. Dr Eng’s two major ground-breaking investigative models on RET and related genes in multiple endocrine neoplasia type 2 (MEN 2; characterized by medullary thyroid cancer, pheochromocytoma and hyperparathyroidism), and PTEN in Cowden syndrome (high risk of breast and thyroid cancers) have been acknowledged as the paradigm for the practice of clinical cancer genetics.

Awards and honors[edit]

  • Elected to the American Society for Clinical Investigation, 2001[1]
  • Doris Duke Distinguished Clinical Scientist Award, 2002
  • Elected to the American Association for the Advancement of Science (AAAS), 2003
  • Elected to the Association of American Physicians (AAP), 2004
  • Local Legend from Ohio, bestowed by the American Medical Women’s Association in conjunction with the US Senate on women physicians who have demonstrated commitment, originality, innovation and/or creativity in their fields of medicine, 2005
  • American Cancer Society Clinical Research Professor, 2009
  • Served on US Department of Health and Human Services Secretary’s Advisory Committee on Genetics, Health and Society, 2009-2011
  • Elected to the National Academy of Medicine, 2010
  • Named as one of 400 most influential biomedical researchers in the world, 2013
  • American Medical Association Women Physicians’ Section Mentorship Recognition, 2013
  • American Medical Women’s Association Exceptional Mentor Award, 2014
  • University of Chicago Medical Alumni Distinguished Service Award, 2015
  • University of Chicago Alumni Association Professional Achievement Award, 2017
  • American Cancer Society (National) Medal of Honor (Clinical Research), 2018
  • Top 0.01% Impactful Scientists (all fields) in the World, 2019
  • AAAS Fellow Special Digital Ribbon for extraordinary achievements advancing science, 2020
  • University of Chicago Laboratory Schools Distinguished Alumna Award, 2021

References[9][edit]

  1. ^ a b c d "Meet Local Legend:Charis Eng, M.D." www.nlm.nih.gov. Retrieved 13 August 2018.
  2. ^ "Charis Eng, MD, PhD". Cleveland Clinic. Retrieved 2019-03-07.
  3. ^ "Interview with Professor Charis Eng" (PDF). p. 4. Retrieved 10 August 2023.
  4. ^ a b Townsend, Angela (14 March 2014). "Cleveland Clinic's Dr. Charis Eng: a Q & A with the cancer geneticist". cleveland.com. Retrieved 13 August 2018.
  5. ^ "Elephant man mystery unravelled", BBC News
  6. ^ "Ancient DNA analysis unveils mystery of history's most horribly deformed man -- The Elephant Man", EurekAlert!
  7. ^ Zhou, Xiao-Ping; Waite, Kristin A.; Pilarski, Robert; Hampel, Heather; Fernandez, Magali J.; Bos, Cindy; Dasouki, Majed; Feldman, Gerald L.; Greenberg, Lois A.; Ivanovich, Jennifer; Matloff, Ellen; Patterson, Annette; Pierpont, Mary Ella; Russo, Donna; Nassif, Najah T.; Eng, Charis (2003). "Germline PTEN Promoter Mutations and Deletions in Cowden/Bannayan-Riley-Ruvalcaba Syndrome Result in Aberrant PTEN Protein and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway". The American Journal of Human Genetics. 73 (2). Elsevier BV: 404–411. doi:10.1086/377109. ISSN 0002-9297. PMC 1180378. PMID 12844284.
  8. ^ Pezzolesi, Marcus G.; Zbuk, Kevin M.; Waite, Kristin A.; Eng, Charis (6 March 2007). "Comparative genomic and functional analyses reveal a novel cis-acting PTEN regulatory element as a highly conserved functional E-box motif deleted in Cowden syndrome". Human Molecular Genetics. 16 (9). Oxford University Press (OUP): 1058–1071. doi:10.1093/hmg/ddm053. ISSN 1460-2083. PMID 17341483.
  9. ^ "Sign Up | LinkedIn". www.linkedin.com. Retrieved 2024-03-20.
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