Lysobisphosphatidic acid
Lysobisphosphatidic acid (LBPA) (also known as bis(monoacylglycero)phosphate (BMP)) is a phospholipid that is found in the membranes of late endosomes and lysosomes of eukaryotic cells.
Phosphatidylglycerol is a precursor and structural isomer of LBPA.[1] LBPA's stereochemistry is atypical among glycerophospholipids and influences its function within the LE/LY (late endosome/lysosome) system.[1][2]
LBPA makes up 15–20% of all LE/LY phospholipids and is not found in other subcellular membranes.[3] LBPA is primarily found within the inner LE/LY membranes where they play a role in their structure and trafficking processes.[1][2] In particular, an interaction between NPC2 and LBPA is necessary for intracellular cholesterol trafficking.[1]
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References[edit]
- ^ a b c d McCauliff, Leslie A; Langan, Annette; Li, Ran; Ilnytska, Olga; Bose, Debosreeta; Waghalter, Miriam; Lai, Kimberly; Kahn, Peter C; Storch, Judith (3 October 2019). "Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid". eLife. 8: e50832. doi:10.7554/eLife.50832. ISSN 2050-084X. PMC 6855803. PMID 31580258.
- ^ a b Goursot, A.; Mineva, T.; Bissig, C.; Gruenberg, J.; Salahub, D. R. (2 December 2010). "Structure, Dynamics, and Energetics of Lysobisphosphatidic Acid (LBPA) Isomers". The Journal of Physical Chemistry B. 114 (47): 15712–15720. doi:10.1021/jp108361d. ISSN 1520-6106. PMID 21053942. Retrieved 9 October 2023.
- ^ Ilnytska, Olga; Jeziorek, Maciej; Lai, Kimberly; Altan-Bonnet, Nihal; Dobrowolski, Radek; Storch, Judith (June 2021). "Lysobisphosphatidic acid (LBPA) enrichment promotes cholesterol egress via exosomes in Niemann Pick type C1 deficient cells". Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 1866 (6): 158916. doi:10.1016/j.bbalip.2021.158916. ISSN 1388-1981. PMC 8038758. PMID 33716137.