Pho1 family
The Pho1 phosphate permease family (TC# 2.A.94) is a family of phosphate transporters belonging to the ion transporter (IT) superfamily.[1] Representative members of the Pho1 family include the putative phosphate transporter PHO1 of Arabidopsis thaliana (TC# 2.A.94.1.1), and the xenotropic and polytropic murine-leukemia virus receptor Xpr1 of Culex pipiens (TC# 2.A.94.1.2).
Pho1[edit]
Pho1 of A. thaliana is a member of the PHO1 family (11 paralogues in A. thaliana). This protein is 782 amino acyl residues in length and possesses 7 transmembrane segments (TMSs). It functions in inorganic phosphate transport and homeostasis. Pho1 catalyzes efflux of phosphate from epidermal and cortical cells into the xylem.[2][3] The SPX superfamily domain is an N-terminal soluble domain. These proteins belong to the EXS (Erd1/Xpr1/Syg1) superfamily.
The generalized reaction catalyzed by Pho1 is:[4]
Pi (cells) → Pi (xylem)
See also[edit]
- Phosphate permease
- Ion transporter superfamily
- Inorganic phosphate
- Transporter Classification Database
Further reading[edit]
- EMBL-EBI, InterPro. "Phosphate permease (IPR004738) < InterPro < EMBL-EBI". www.ebi.ac.uk. Retrieved 2016-03-03.
- "pho-4 - Phosphate-repressible phosphate permease pho-4 - Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) - pho-4 gene & protein". www.uniprot.org. Retrieved 2016-03-03.
- Versaw, W. K. (1995-02-03). "A phosphate-repressible, high-affinity phosphate permease is encoded by the pho-5+ gene of Neurospora crassa". Gene 153 (1): 135–139. ISSN 0378-1119. PMID 7883177.
- Ramaiah, Madhuvanthi; Jain, Ajay; Baldwin, James C.; Karthikeyan, Athikkattuvalasu S.; Raghothama, Kashchandra G. (2011-09-01). "Characterization of the phosphate starvation-induced glycerol-3-phosphate permease gene family in Arabidopsis". Plant Physiology157 (1): 279–291. doi:10.1104/pp.111.178541. ISSN 1532-2548. PMC 3165876. PMID 21788361.
- Stakheev, A. A.; Khairulina, D. R.; Ryazantsev, D. Yu; Zavriev, S. K. (2013-03-22). "Phosphate permease gene as a marker for the species-specific identification of the toxigenic fungus Fusarium cerealis". Russian Journal of Bioorganic Chemistry 39 (2): 153–160.doi:10.1134/S1068162013020131. ISSN 1068-1620.
References[edit]
- ^ Prakash, Shraddha; Cooper, Garret; Singhi, Soumya; Saier, Milton H. (2003-12-03). "The ion transporter superfamily". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. ISSN 0006-3002. PMID 14643936.
- ^ Quaghebeur, Mieke; Rengel, Zed (2004-02-01). "Arsenic uptake, translocation and speciation in pho1 and pho2 mutants of Arabidopsis thaliana". Physiologia Plantarum. 120 (2): 280–286. doi:10.1111/j.0031-9317.2004.0240.x. ISSN 1399-3054. PMID 15032863.
- ^ Stefanovic, Aleksandra; Ribot, Cécile; Rouached, Hatem; Wang, Yong; Chong, Julie; Belbahri, Lassaad; Delessert, Syndie; Poirier, Yves (2007-06-01). "Members of the PHO1 gene family show limited functional redundancy in phosphate transfer to the shoot, and are regulated by phosphate deficiency via distinct pathways". The Plant Journal. 50 (6): 982–994. doi:10.1111/j.1365-313X.2007.03108.x. ISSN 0960-7412. PMID 17461783.
- ^ "2.A.94 The Phosphate Permease (Pho1) Family". Transporter Classification Database. Retrieved 2016-03-03.
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