Proteasome ATPase
| Proteasome ATPase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.6.4.8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a proteasome ATPase (EC 3.6.4.8) is an enzyme that catalyzes the chemical reaction
- ATP + H2O ADP + phosphate
Thus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to facilitate cellular and subcellular movement. The systematic name of this enzyme class is ATP phosphohydrolase (polypeptide-degrading).
References[edit]
- Rivett AJ, Mason GG, Murray RZ, Reidlinger J (1997). "Regulation of proteasome structure and function". Mol. Biol. Rep. 24 (1–2): 99–102. doi:10.1023/A:1006814306401. PMID 9228289.
- Mason GG, Murray RZ, Pappin D, Rivett AJ (1998). "Phosphorylation of ATPase subunits of the 26S proteasome". FEBS Lett. 430 (3): 269–74. doi:10.1016/S0014-5793(98)00676-0. PMID 9688553.
