SLC22A13

SLC22A13
Identifiers
Aliases	SLC22A13, OAT10, OCTL1, OCTL3, ORCTL-3, ORCTL3, solute carrier family 22 member 13
External IDs	OMIM: 604047 MGI: 2143107 HomoloGene: 3140 GeneCards: SLC22A13
Gene location (Human) Chr. Chromosome 3 (human) Band 3p22.2 Start 38,265,812 bp End 38,278,757 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F3 Start 119,022,040 bp End 119,038,164 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney renal cortex stromal cell of endometrium metanephros blood cerebellum cerebellar cortex gastrocnemius muscle cerebellar hemisphere prefrontal cortex Top expressed in kidney proximal tubule proximal straight tubule morula thyroid gland proximal convoluted tubule Greater petrosal nerve right ventricle ascending aorta jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function transmembrane transporter activity organic cation transmembrane transporter activity nicotinate transmembrane transporter activity inorganic anion exchanger activity sodium-independent organic anion transmembrane transporter activity Cellular component integral component of plasma membrane apical plasma membrane membrane extracellular exosome integral component of membrane plasma membrane Biological process nicotinate transport transmembrane transport urate transport organic cation transport NAD biosynthesis via nicotinamide riboside salvage pathway inorganic anion transport sodium-independent organic anion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9390 102570 Ensembl ENSG00000172940 ENSMUSG00000074028 UniProt Q9Y226 Q6A4L0 RefSeq (mRNA) NM_004256 NM_133980 RefSeq (protein) NP_004247 NP_598741 Location (UCSC) Chr 3: 38.27 – 38.28 Mb Chr 9: 119.02 – 119.04 Mb PubMed search
Wikidata
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Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene.

Function

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine.

Further reading

• Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, Burckhardt BC, Sabolic I, Burckhardt G (2008). "Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)". J. Biol. Chem. 283 (24): 16332–41. doi:10.1074/jbc.M800737200. PMID 18411268.
• Irshad S, Mahul-Mellier AL, Kassouf N, Lemarie A, Grimm S (2009). "Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers". Cell Death Differ. 16 (6): 890–8. doi:10.1038/cdd.2009.21. PMC 2683172. PMID 19282870.
• Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, Sabolić I, Koepsell H, Brockmöller J (2009). "The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin". Clin. Pharmacol. Ther. 86 (3): 299–306. doi:10.1038/clpt.2009.92. PMID 19536068. S2CID 8583867.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Schulz C, Fork C, Bauer T, Golz S, Geerts A, Schömig E, Gründemann D (2014). "SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct". Biochem. J. 457 (2): 243–51. doi:10.1042/BJ20130654. PMID 24147638.
• AbuAli G, Chaisaklert W, Stelloo E, Pazarentzos E, Hwang MS, Qize D, Harding SV, Al-Rubaish A, Alzahrani AJ, Al-Ali A, Sanders TA, Aboagye EO, Grimm S (2015). "The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis". Oncogene. 34 (13): 1718–28. doi:10.1038/onc.2014.93. PMC 4119473. PMID 24769897.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.