TRPM7

TRPM7
Identifiers
Aliases	TRPM7, ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK, transient receptor potential cation channel subfamily M member 7
External IDs	OMIM: 605692 MGI: 1929996 HomoloGene: 9774 GeneCards: TRPM7
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.2 Start 50,552,473 bp End 50,686,797 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 F1 Start 126,633,485 bp End 126,718,150 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve gastric mucosa right lobe of liver stromal cell of endometrium bone marrow cells islet of Langerhans monocyte rectum appendix Top expressed in molar parotid gland saccule pineal gland atrium dermis iris seminal vesicula retinal pigment epithelium ectoderm More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding myosin binding metal ion binding kinase activity protein serine/threonine kinase activity ion channel activity actin binding ATP binding calcium channel activity Cellular component integral component of membrane membrane ruffle plasma membrane Biological process cellular magnesium ion homeostasis calcium-dependent cell-matrix adhesion programmed cell death phosphorylation actomyosin structure organization cation transport ion transport protein tetramerization protein phosphorylation calcium ion transmembrane transport protein autophosphorylation necroptosis calcium ion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54822 58800 Ensembl ENSG00000092439 ENSMUSG00000027365 UniProt Q96QT4 Q923J1 RefSeq (mRNA) NM_001301212 NM_017672 NM_001164325 NM_021450 RefSeq (protein) NP_001288141 NP_060142 NP_001157797 NP_067425 Location (UCSC) Chr 15: 50.55 – 50.69 Mb Chr 2: 126.63 – 126.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.

Function

TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.

Interactions

TRPM7 has been shown to interact with PLCB1 and PLCB2.

Clinical relevance

Defects in this gene have been associated with magnesium deficiency in human microvascular endothelial cells.

See also

• TRPM

Further reading

• Chubanov V, Gudermann T, Schlingmann KP (2005). "Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis". Pflügers Arch. 451 (1): 228–34. doi:10.1007/s00424-005-1470-y. PMID 16075242. S2CID 6037803.
• Clapham DE, Julius D, Montell C, Schultz G (2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
• Penner R, Fleig A (2007). "The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. Vol. 179. pp. 313–28. doi:10.1007/978-3-540-34891-7_19. ISBN 978-3-540-34889-4. PMC 5663631. PMID 17217066.

External links

• TRPM7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.