Talk:BRCA2

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Untitled[edit]

Some text in this article was originally taken from http://ghr.nlm.nih.gov/gene=brca2 (public domain)

BRCA1 substitution[edit]

Presumably damage to either one of BRCA1 or BRCA2 leads to problems so they can not substitute for each other ? Does that mean that both BRCA1 and BRCA2 must work together for effective DNA repair ? Rod57 (talk) 15:01, 10 February 2010 (UTC)[reply]

To what extent do they repair single strand DNA breaks ? Rod57 (talk) 15:01, 10 February 2010 (UTC)[reply]

Bicycle trail[edit]

The bicycle trail is interesting, but is the information too tangential and the passage too long for this article? An anecdotal image alone, versus an entire paragraph, may be more appropriate. — Preceding unsigned comment added by Leedmcdaniel (talk • contribs) 18:13, 3 October 2012 (UTC)[reply]

Assessment comment[edit]

The comment(s) below were originally left at Talk:BRCA2/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

It is good that at least a stub is present on the BRCA genes. However, it would be best if both of these were extensively modified. As a first pass, I'd like to see the following:

1. Differential between genetic/familial breast csncers in age of onset (BRCA mutations are far more common in early onset disease) 2. Discussion of associated risks including recurrence on the other side, risks to males carrying mutations, and risks to first degree relatives. 3. Discussion of other cancers at increased risk in BRCA mutaion carriers 4. discussion of differences in clinical presentation of BRCA1 vs BRCA2 carriers 5. Increased prevalence of mutations in Ashkenazi jews

This is not my specific field, and it would be great for a specialist to edit these.

Last edited at 23:25, 23 June 2007 (UTC). Substituted at 08:47, 29 April 2016 (UTC)

moved out of unassessed on the genetics project[edit]

1/15/17 DennisPietras (talk) 02:37, 16 January 2017 (UTC)[reply]

link to brcaexchange.org[edit]

Please see Wikipedia_talk:WikiProject_Molecular_and_Cell_Biology#brcaexchange.org -- Jytdog (talk) 19:38, 11 July 2017 (UTC)[reply]

Clinical significance section[edit]

The expression "cancer pathogen" appears in this section, and I am having a hard time figuring out what is meant by the term. It's an uncommon term on the Internet, and apparently refers to a microbe which is believed to cause "cancer", in plants or animals. In the section, the term is introduced as if its meaning is already known, yet there is no such WP article or earlier mention of such an entity in the article. I feel that either this is a WP: FRINGE or bad writing, and should be fixed, but I am not deeply knowledgeable on this topic. Can anyone sort it out, please? Thanks for your efforts.--Quisqualis (talk) 19:54, 18 February 2018 (UTC)[reply]

History section[edit]

After I removed some tangential filler about a walking path, the graphic presentation in this section appears compromised. All the text appears below the images, which are paired with a large chunk of white space. The fundamental problem here is the large number of infoboxes. I think moving the History section further down the page is the best solution. Can anyone figure out a better way to fix this?--Quisqualis (talk) 20:14, 18 February 2018 (UTC)[reply]