Talk:HLA A1-B8-DR3-DQ2

Citations do not correspond to tagged material

The citation to reference 4 re: 15% of the Caucasion American population bearing the haplotype in question is wrong. I searched end to end through the paper and couldn't find anything about its frequency. I've not checked yet if other citations are similarly erroneous. I think that what happened is that references got shuffled or added and the citation marks didn't. Karajade (talk) 03:37, 14 November 2009 (UTC)

I believe the cited 0.15 is calculated from an observed count of 995.1 in a (2N) sample size of 12,770, for an allele frequency of 0.0779. Taking 0.0779 as p in Hardy-Weinburg equilibrium, we can calculate the frequency of the allele in the population as p*p + 2*p*(1-p) = 0.006 + 0.143 = 0.149, or about 15% 143.197.222.231 (talk) 13:26, 10 March 2014 (UTC) Tait 3/10/2014

Please add polymyositis and dermatomyositis

Recent research by the United States NIH/NIEHS confirms that this ancestral haplotype is the primary genetic risk factor for polymyositis and dermatomyositis, not just inclusion body myositis. Here are links to the overview and the abstract:

"Genes strongly associated with myositis risk identified"

PubMed abstract: "Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes." Genes Immun. 2015 Oct;16(7):470-80. doi: 10.1038/gene.2015.28. Epub 2015 Aug 20.

Please add these two autoimmune diseases to the narrative. Thank you.

207.87.104.186 (talk) 15:47, 19 November 2015 (UTC)

References

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