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| mir-19 microRNA precursor family | |
|---|---|
 Predicted secondary structure and sequence conservation of mir-19 | |
| Identifiers | |
| Symbol | mir-19 |
| Rfam | RF00245 |
| miRBase | MI0000073 |
| miRBase family | MIPF0000011 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | GO:0035195 GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
The miR-19 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. Within the human and mouse genome there are three copies of this microRNA that are processed from multiple predicted precursor hairpins:[1][2] [3]
miR-19 has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000011). In this case the mature sequence is excised from the 3' arm of the hairpin precursor.
Targets of miR-19[edit]
It has been shown that the 3' UTR of the ATXN1 gene contains 3 target sites for miR-19, and that this microRNA shows moderate down regulation of reporter genes containing the ATXN1 3' UTR. ATXN1 is also regulated by miR-101, and miR-130.[4]
References[edit]
- ^ Lagos-Quintana, Mariana; Rauhut, Reinhard; Lendeckel, Winfried; Tuschl, Thomas (2001). "Identification of novel genes coding for small expressed RNAs". Science. 294 (5543): 853–858. doi:10.1126/science.1064921. PMID 11679670.
{{cite journal}}: CS1 maint: date and year (link) - ^ Mourelatos, Zissimos; Dostie, Josée; Paushkin, Sergey; Sharma, Anup; Charroux, Bernard; Abel, Linda; Rappsilber, Juri; Mann, Matthias; Dreyfuss, Gideon (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–728. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.
{{cite journal}}: CS1 maint: date and year (link) - ^ Houbaviy, Hristo B.; Murray, Michael F.; Sharp, Phillip A. (2003). "Embryonic stem cell-specific MicroRNAs". Dev Cell. 5 (2): 351–358. doi:10.1016/S1534-5807(03)00227-2. PMID 12919684.
{{cite journal}}: CS1 maint: date and year (link) - ^ Lee Y, Samaco RC, Gatchel JR, Thaller C, Orr HT, Zoghbi HY (October 2008). "miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis". Nat. Neurosci. 11 (10): 1137–9. doi:10.1038/nn.2183. PMC 2574629. PMID 18758459.
{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)
External links[edit]
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