User:Dusty Zeliff/sandbox

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Commonly Used Inbred Strains[edit]

There are many strains of mice used in research, however, inbred strains are usually the animals of choice for most fields. Inbred mice are defined as being the product of at least 20 generations of brother X sister mating, with all individuals being derived from a single breeding pair.[1]

Inbred mice have several traits that make them ideal for research purposes. They are isogenic, meaning that all animals are nearly genetically identical.[2] Approximately 98.7% of the genetic loci in the genome are homozygous, so there are no "hidden" recessive traits that could cause problems.[3] They also have very unified phenotypes due to this stability.[4]

Many inbred strains have well documented traits that make them ideal for specific types of research. These are the top 10 most popular strains according to Jackson Laboratories.

Common Inbred Strains of Laboratory Mice Available from Jackson Laboratories
Strain Coat Color[5] Common Research Uses Total Pubmed Publications Referencing the Strain as of 4/19/2023[6]
C3HeB/FeJ Agouti Immunology, Inflammation, Autoimmunity[7] 482
NOD/ShiLtJ Albino Autoimmune Type 1 Diabetes[8] 105
DBA/1J Dilute Brown Rheumatoid Arthritis[9] 445
BALB/cByJ Albino Cancer, Cardiovascular, Immunology[10] 628
DBA/2J Dilute Brown Cardiovascular, Dermatology, Developmental Biology[11] 2,722
C3H/HeJ Agouti Cancer, Cardiovascular, Hematology[12] 4,037
C57BL/6J Black General Purpose, Background[13] 25,723
SJL/J Albino Cancer, Cardiovascular, Dermatology[14] 1,448
FVB/NJ Albino Immunology, Inflammation, Autoimmunity[15] 350
129S1/SvImJ Agouti Targeted Mutations, Cancer[16] 222


Jackson Labs DO Project

The Jackson Labs DO (Diversity Outbred)

Phylogenetic tree of the eight founder strains used in the DO project, as well as their approximate age of divergence. M. spretus is included as an outgroup that diverged ~2 million years ago (mya), it is not part of the DO project[17].

project[18] is a mouse breeding program using multiple inbred founder strains to create a genetically diverse population of mice for use in scientific research.

These mice are designed for fine genetic mapping, and capture a large portion of the genetic diversity of the mouse genome.[19]

This project has resulted in over 1,000 genetically diverse mice which have been used to identify genetic factors for diseases such as obesity, cancer, diabetes, and alcohol use disorder. [20]

Founder Strains Used in the DO Project
Strain Derivation Subspecies Origin Coat Color[21] Common Research Uses Total Pubmed Publications Referencing the Strain as of 4/19/2023
A/J Laboratory Mus musculus domesticus[22] Albino Cancer, Immunology[23] 5,500
C57BL/6J Laboratory Mus musculus domesticus[24] Black General Purpose, Background[25] 25,723
129S1/SvImJ Laboratory Mus musculus domesticus Agouti[26] Targeted Mutations, Cancer[27] 222
NOD/ShiLtJ Laboratory Mus musculus domesticus[28] Albino Autoimmune Type 1 Diabetes[29] 105
NZO/HILtJ Laboratory Mus musculus domesticus[30] Agouti Obesity[31] 11
CAST/EiJ Wild-Derived Mus musculus castanus[32] Agouti Crossbreeding Heterozygous F1 Hybrids, Genetic Mapping[33] 154
PWK/PhJ Wild-Derived Mus musculus musculus [34] Agouti Genetic Mapping[35] 52
WSB/EiJ Wild-Derived Mus musculus domesticus[36] Agouti with head blaze, greyish coat Genetic Mapping, Evolution[37] 65
  1. ^ https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/inbred-strain
  2. ^ https://doi.org/10.1016/B978-0-12-374984-0.00781-6
  3. ^ https://doi.org/10.1016/B978-0-12-374984-0.00781-6
  4. ^ https://doi.org/10.1016/B978-0-12-374984-0.00781-6
  5. ^ https://jackson.jax.org/rs/444-BUH-304/images/Poster_Mouse_Coat_Color.pdf
  6. ^ https://pubmed.ncbi.nlm.nih.gov/
  7. ^ https://www.jax.org/strain/000658
  8. ^ https://www.jax.org/strain/001976
  9. ^ https://www.jax.org/strain/000670
  10. ^ https://www.jax.org/strain/001026
  11. ^ https://www.jax.org/strain/000671
  12. ^ https://www.jax.org/strain/000659
  13. ^ https://www.jax.org/strain/000664
  14. ^ https://www.jax.org/strain/000686
  15. ^ https://www.jax.org/strain/001800
  16. ^ https://www.jax.org/strain/002448
  17. ^ doi: 10.1007/s00335-015-9581-z
  18. ^ https://www.jax.org/research-and-faculty/genetic-diversity-initiative
  19. ^ https://doi.org/10.1016/j.tig.2019.04.003
  20. ^ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571031/
  21. ^ https://jackson.jax.org/rs/444-BUH-304/images/Poster_Mouse_Coat_Color.pdf
  22. ^ https://pubmed.ncbi.nlm.nih.gov/26135136/
  23. ^ https://www.jax.org/strain/000646
  24. ^ https://pubmed.ncbi.nlm.nih.gov/26135136/
  25. ^ https://www.jax.org/strain/000664
  26. ^ https://www.jax.org/strain/002448
  27. ^ https://www.jax.org/strain/002448
  28. ^ https://pubmed.ncbi.nlm.nih.gov/26135136/
  29. ^ https://www.jax.org/strain/001976
  30. ^ https://pubmed.ncbi.nlm.nih.gov/26135136/
  31. ^ https://www.jax.org/strain/002105
  32. ^ https://pubmed.ncbi.nlm.nih.gov/26135136/
  33. ^ https://www.jax.org/strain/000928
  34. ^ https://pubmed.ncbi.nlm.nih.gov/26135136/
  35. ^ https://www.jax.org/strain/003715
  36. ^ https://pubmed.ncbi.nlm.nih.gov/26135136/
  37. ^ https://www.jax.org/strain/001145
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