User:Mr. Ibrahem/Balsalazide

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Mr. Ibrahem/Balsalazide
Clinical data
Trade namesColazide,[1] Giazo, Colazal[2]
Other namesBalsalazide sodium, balsalazide disodium[1]
AHFS/Drugs.comMonograph
MedlinePlusa699052
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
Drug classProdrug of mesalamine[3]
Legal status
Legal status
Pharmacokinetic data
Bioavailability<1%
Protein binding≥99%
Elimination half-life12hr
Identifiers
  • (E)-5-([4-(2-carboxyethylcarbamoyl)phenyl]diazenyl)-2-hydroxybenzoic acid
Chemical and physical data
FormulaC17H15N3O6
Molar mass357.322 g·mol−1
3D model (JSmol)
  • O=C(O)c1cc(ccc1O)/N=N/c2ccc(cc2)C(=O)NCCC(O)=O
  • InChI=1S/C17H15N3O6/c21-14-6-5-12(9-13(14)17(25)26)20-19-11-3-1-10(2-4-11)16(24)18-8-7-15(22)23/h1-6,9,21H,7-8H2,(H,18,24)(H,22,23)(H,25,26)/b20-19+ checkY
  • Key:IPOKCKJONYRRHP-FMQUCBEESA-N checkY
 ☒NcheckY (what is this?)  (verify)

Balsalazide, sold under the brand name Colazide among others, is a medication used to treat ulcerative colitis (UC) and Crohn's disease.[1][3] In UC it is used for mild to moderate disease and usually only for up to 12 weeks.[3] It is take by mouth.[1]

Common side effects include headache, feeling sick, stomach upset, diarrhea, joint pain, and respiratory infections.[3] Other side effects may include blood disorder, gallstones, or a lupus-like syndrome.[1] Safety in pregnancy is unclear.[6] An alternative may be required for people with asthma, kidney or liver problems.[1] Balsalazide passes unchanged through the stomach and small bowel, and releases mesalazine (5-ASA) when it reaches the large bowel, where ulcerative colitis affects.[7]

Balsalazide was first made in the 1980s and approved for medical use in the United Kingdom in 1997.[8] It is available as a generic medication.[9] In the United Kingdom a months supply at the maintenance dose costs the NHS around £30 as of 2021.[1] In the United States this amount costs about US$74.[10]

References[edit]

  1. ^ a b c d e f g h "1. Gastro-intestinal system". British National Formulary (BNF) (82 ed.). London: BMJ Group and the Pharmaceutical Press. September 2021 – March 2022. pp. 44–45. ISBN 978-0-85711-413-6.{{cite book}}: CS1 maint: date format (link)
  2. ^ "A - Z Drug List from Drugs.com: Balsalazide". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 22 November 2021. Retrieved 22 November 2021.
  3. ^ a b c d e f "Balsalazide Monograph for Professionals". Drugs.com. Archived from the original on 18 December 2021. Retrieved 8 January 2022.
  4. ^ "Colazide 750mg Capsules - Summary of Product Characteristics (SmPC)". (emc). 3 January 2019. Archived from the original on 22 January 2021. Retrieved 2 October 2020.
  5. ^ "Balsalazide Use During Pregnancy". Drugs.com. Archived from the original on 1 December 2020. Retrieved 22 November 2021.
  6. ^ "Balsalazide Use During Pregnancy". Drugs.com. Archived from the original on 1 December 2020. Retrieved 8 January 2022.
  7. ^ McQuaid, Kenneth R. (2020). "62. Drugs used in the treatment of gastrointestinal diseases". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (15th ed.). New York: McGraw-Hill. pp. 1150–1151. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-11-22.
  8. ^ Richmond, Lesley; Stevenson, Julie (2017). The Pharmaceutical Industry: A Guide to Historical Records. Routledge. p. 135. ISBN 978-1-351-88429-7. Archived from the original on 2021-12-11. Retrieved 2021-11-23.
  9. ^ "Balsalazide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 23 October 2016. Retrieved 8 January 2022.
  10. ^ "Balsalazide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 8 January 2022.
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