User:Mr. Ibrahem/Brinzolamide

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Mr. Ibrahem/Brinzolamide
Clinical data
Pronunciationbrin ZOH la mide
Trade namesAzopt, Befardin, others
AHFS/Drugs.comMonograph
MedlinePlusa601233
License data
Pregnancy
category
Routes of
administration		Eye drop
Drug classCarbonic anhydrase inhibitor[2]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only
  • EU: Rx-only
Pharmacokinetic data
BioavailabilityAbsorbed systemically, but below detectable levels (less than 10 ng/mL)
Protein binding~60%
Elimination half-life111 days
ExcretionKidney (60%)
Identifiers
  • (5R)-5-ethylamino-3-(3-methoxypropyl)-
    2,2-dioxo-2λ6,9-dithia-
    3-azabicyclo[4.3.0]nona-7,10-diene-
    8-sulfonamide
Chemical and physical data
FormulaC12H21N3O5S3
Molar mass383.50 g·mol−1
3D model (JSmol)
  • O=S(=O)(c1sc2c(c1)[C@@H](NCC)CN(CCCOC)S2(=O)=O)N
  • InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1 checkY
  • Key:HCRKCZRJWPKOAR-JTQLQIEISA-N checkY
  (verify)

Brinzolamide, sold under the brand name Azopt among others, is a medication used to treat glaucoma, specifically open-angle glaucoma.[2] It is often used together with beta blockers or prostaglandin analogues.[3] It is used as an eye drop.[2]

Common side effects include a bitter taste in the mouth and temporary blurry vision.[3] Safety in pregnancy is unclear.[4] It is a carbonic anhydrase inhibitor, which decreases the production of aqueous humour.[2][3]

Brinzolamide was approved for medical use in the United States in 1998 and Europe in 2000.[2][3] Generic versions were approved in 2020.[5] In the United Kingdom 5 ml costs the NHS about £3 as of 2021.[6] This amount in the United States is about 47 USD.[7]

References[edit]

  1. ^ "Brinzolamide ophthalmic (Azopt) Use During Pregnancy". Drugs.com. 16 May 2019. Archived from the original on 28 November 2020. Retrieved 17 August 2020.
  2. ^ a b c d e f "Brinzolamide Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 11 January 2022.
  3. ^ a b c d e "Azopt". Archived from the original on 29 April 2021. Retrieved 11 January 2022.
  4. ^ "Brinzolamide". Archived from the original on 19 April 2021. Retrieved 11 January 2022.
  5. ^ Research, Center for Drug Evaluation and (23 February 2021). "2020 First Generic Drug Approvals". FDA. Archived from the original on 26 September 2021. Retrieved 11 January 2022.
  6. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1226. ISBN 978-0857114105.
  7. ^ "Brinzolamide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 2 October 2016. Retrieved 11 January 2022.
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