User:Mr. Ibrahem/Candesartan

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Mr. Ibrahem/Candesartan
Clinical data
Pronunciation/ˌkændɪˈsɑːrtən/
Trade namesAtacand, others
Other namesCandesartan cilexetil
AHFS/Drugs.comMonograph
MedlinePlusa601033
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
Drug classAngiotensin II receptor blocker (ARB)[1]
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability15% (candesartan cilexetil)
MetabolismCandesartan cilexetil: intestinal wall; candesartan: liver (CYP2C9)
Elimination half-life9 hours
ExcretionKidney 33%, faecal 67%
Identifiers
  • 2-ethoxy-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-1,3-benzodiazole-7-carboxylic acid
Chemical and physical data
FormulaC24H20N6O3
Molar mass440.463 g·mol−1
3D model (JSmol)
  • CCOc2nc1cccc(C(=O)O)c1n2Cc5ccc(c3ccccc3c4nn[nH]n4)cc5
  • InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29) checkY
  • Key:HTQMVQVXFRQIKW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Candesartan is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[1][2] In high blood pressure, it is one of a number of possible first line agents.[2] It is taken by mouth.[2]

Common side effects include headache, dizziness, tiredness, cough, and gastrointestinal upset.[3] Other side effects may include high potassium, low blood pressure, and kidney problems.[1] Use in pregnancy may harm the baby.[3] It is a angiotensin II receptor blocker (ARB).[1]

Candesartan was patented in 1990 and approved for medical use in 1997.[4] It is available as a generic medication.[5] In the United States a month of 32 mg costs about 25 USD as of 2021.[6] In the United Kingdom this amount costs the NHS about £2.[5]

References[edit]

  1. ^ a b c d e "DailyMed - CANDESARTAN tablet". dailymed.nlm.nih.gov. Archived from the original on 7 February 2019. Retrieved 29 December 2021.
  2. ^ a b c d "Candesartan Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 29 December 2021.
  3. ^ a b c "Candesartan". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 27 August 2021. Retrieved 29 December 2021.
  4. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 471. ISBN 9783527607495. Archived from the original on 2021-10-31. Retrieved 2021-10-24.
  5. ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 189. ISBN 978-0857114105.
  6. ^ "Candesartan Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 October 2021. Retrieved 29 December 2021.
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