User:Mr. Ibrahem/Chlorzoxazone
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| Clinical data | |
|---|---|
| Pronunciation | klor zox' a zone[1] |
| Trade names | Lorzone, Paraflex, Muscol, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682577 |
| License data | |
| Routes of administration | By mouth |
| Drug class | Muscle relaxant[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | Well absorbed |
| Protein binding | 13–18% |
| Metabolism | Liver |
| Onset of action | With 1 hr[4] |
| Elimination half-life | 1.1 hr |
| Duration of action | Up to 4 hr[4] |
| Excretion | Urine (<1%) |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C7H4ClNO2 |
| Molar mass | 169.56 g·mol−1 |
| 3D model (JSmol) | |
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| (verify) | |
Chlorzoxazone, sold under the brand names Lorzone among others, is a muscle relaxant used to treat low back pain and muscle spasms.[1] Benefits are moderate.[1] It is not useful for neurological problems such as cerebral palsy.[4] It is taken by mouth.[1] Effects begin within an hour and last for up to 4 hours.[4]
Common side effects include dizziness, sleepiness, headache, and tremor.[1] Other side effects may include liver problems and angioedema.[1][4] Safety in pregnancy is unclear.[4] It works at the level of the spinal cord and brain.[4]
Chlorzoxazone was approved for medical use in the United States in 1958.[1] It is available as a generic medication.[1] In the United States 60 pills of 500 mg costs about 18 USD as of 2022.[5] As of 2017 it remains widely used.[1]
References[edit]
- ^ a b c d e f g h i j k l "Chlorzoxazone". Archived from the original on 8 May 2021. Retrieved 4 January 2022.
- ^ "Parafon DSC- chlorzoxazone tablet". DailyMed. 9 February 2010. Archived from the original on 16 March 2021. Retrieved 5 November 2020.
- ^ "Lorzone- chlorzoxazone tablet". DailyMed. 21 June 2019. Archived from the original on 12 November 2020. Retrieved 5 November 2020.
- ^ a b c d e f g "Chlorzoxazone Monograph for Professionals". Drugs.com. Archived from the original on 28 November 2021. Retrieved 4 January 2022.
- ^ "Chlorzoxazone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 5 November 2016. Retrieved 4 January 2022.