User:Mr. Ibrahem/Clemastine

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Mr. Ibrahem/Clemastine
Clinical data
Trade namesTavegil, Dayhist, Tavist, others
Other namesClemastine fumarate, meclastin, mecloprodin
AHFS/Drugs.comMonograph
MedlinePlusa682542
Routes of
administration		By mouth
Drug class1st-generation antihistamine[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability39.2%
MetabolismLiver
Elimination half-life21.3 hours
ExcretionKidney
Identifiers
  • (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine
Chemical and physical data
FormulaC21H26ClNO
Molar mass343.90 g·mol−1
3D model (JSmol)
  • Clc1ccc(cc1)[C@](OCC[C@@H]2N(C)CCC2)(c3ccccc3)C
  • InChI=1S/C21H26ClNO/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3/t20-,21-/m1/s1 checkY
  • Key:YNNUSGIPVFPVBX-NHCUHLMSSA-N checkY
  (verify)

Clemastine, also known as meclastin, is a medication used to treat allergies such as hay fever and hives.[2][3] It may also be used for symptoms of the common cold.[1] It is taken by mouth.[2]

Common side effects include sleepiness, dizziness, poor coordination, and an upset stomach.[1] Other side effects may include agitation, dry mouth, and constipation.[2] There is no evidence of harm with use in pregnancy, but such use has not been well studied.[4] It should not be used when breastfeeding.[1] It is a first-generation antihistamine.[1]

Patented in 1960, it came into medical use in 1967.[5] It is available as a generic medication and over the counter.[1] In the United Kingdom 60 pills of 1 mg costs the NHS about £7 as of 2021.[2] This amount in the United States costs about 18 USD.[6]

References[edit]

  1. ^ a b c d e f g "Clemastine Monograph for Professionals". Drugs.com. Archived from the original on 12 June 2021. Retrieved 5 January 2022.
  2. ^ a b c d e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 300. ISBN 978-0857114105.
  3. ^ "Clemastine [USAN:INN:BAN]". Archived from the original on 2 May 2021. Retrieved 5 January 2022.
  4. ^ "Clemastine Use During Pregnancy". Drugs.com. Archived from the original on 3 December 2020. Retrieved 5 January 2022.
  5. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 547. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-08-25.
  6. ^ "Clemastine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 5 January 2022.
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