User:Mr. Ibrahem/Desvenlafaxine

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Mr. Ibrahem/Desvenlafaxine
Skeletal formula
Ball-and-stick model of desvenlafaxine
Clinical data
Trade namesPristiq, Desfax, Ellefore, others
Other namesO-desmethylvenlafaxine
AHFS/Drugs.comMonograph
MedlinePlusa608022
License data
Pregnancy
category
  • AU: B2
Routes of
administration		By mouth
Drug classSerotonin-norepinephrine reuptake inhibitor[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability80%
Protein bindingLow (30%)
MetabolismCYP3A4, (CYP2D6 is not involved)
Elimination half-life11 h
Excretion45% excreted unchanged in urine
Identifiers
  • 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)
    ethyl]phenol
Chemical and physical data
FormulaC16H25NO2
Molar mass263.381 g·mol−1
3D model (JSmol)
  • OC2(C(c1ccc(O)cc1)CN(C)C)CCCCC2
  • InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3 checkY
  • Key:KYYIDSXMWOZKMP-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Desvenlafaxine, sold under the brand name Pristiq among others, is a medication used to treat major depressive disorder.[1] It is recommended that the need for further treatment be occasionally reassessed.[1] It appears less effective than its parent compound venlafaxine.[3] It is taken by mouth.[1]

Common side effects include dizziness, trouble sleeping, increased sweating, constipation, sleepiness, anxiety, and sexual problems.[1] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and high blood pressure.[1] A withdrawal syndrome may occur if the dose is rapidly decreased.[1] It is unclear if use during pregnancy or breastfeeding is safe.[4] It is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.[1]

Desvenlafaxine was approved for medical use in the United States in 2008.[1] Use in Europe was declined in 2009.[3] In the United States the wholesale cost is about 25.20 USD per month.[5] In 2017, it was the 235th most commonly prescribed medication in the United States, with more than two million prescriptions.[6][7]

References[edit]

  1. ^ a b c d e f g h i j "Desvenlafaxine Succinate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 29 March 2019. Retrieved 18 March 2019.
  2. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 21 January 2021. Retrieved 7 September 2020.
  3. ^ a b "Withdrawal Assessment Report for Dessvenlafaxime" (PDF). EMA. p. 3. Archived (PDF) from the original on 22 March 2019. Retrieved 22 March 2019.
  4. ^ "Desvenlafaxine Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 29 November 2018. Retrieved 19 March 2019.
  5. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
  6. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  7. ^ "Desvenlafaxine - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
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