User:Mr. Ibrahem/Droperidol

From Wikipedia, the free encyclopedia
Not to be confused with Dronabinol or Domperidone.
Mr. Ibrahem/Droperidol
Skeletal formula of droperidol
Ball-and-stick model of droperidol
Clinical data
Pronunciation/droʊˈpɛrIdɔːl/
Trade namesInapsine, Droleptan, Dridol, others
AHFS/Drugs.comMonograph
Pregnancy
category
  • AU: C
Routes of
administration		Intravenous, intramuscular[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
MetabolismLiver
Onset of action< 10 min[1]
Elimination half-life2.3 hours
Duration of actionUp to 12 hrs[1]
Identifiers
  • 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
Chemical and physical data
FormulaC22H22FN3O2
Molar mass379.435 g·mol−1
3D model (JSmol)
  • c1ccc2c(c1)nc(n2C3=CCN(CC3)CCCC(=O)c4ccc(cc4)F)O

  • Fc1ccc(cc1)C(=O)CCCN2CC=C(CC2)N3c4ccccc4NC3=O
  • InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)
  • Key:RMEDXOLNCUSCGS-UHFFFAOYSA-N

Droperidol is a medication used to prevent and treat nausea and vomiting including that due to chemotherapy.[1] It has also been used for sedative in those who are agitated and during anesthesia and for migraines.[1][2] It is given by injection into a vein or muscle.[1] Onset is within 10 minutes with a maximum effect up to 30 minutes.[1] Effects may last up to 12 hours.[1]

Common side effects include low blood pressure, movement disorders, fast heart rate, and sleepiness.[1] Other concerns include QT prolongation, and neuroleptic malignant syndrome.[1] Safety during pregnancy and breastfeeding is unclear.[3] It is in the butyrophenone family of medication and works by blocking dopamine receptors.[4]

Droperidol came into medical use in 1967.[5] It is available as a generic medication.[4] In 2001 the company making it stopped doing so.[5] It historically has been inexpensive.[5] Availability improved in 2019 as a new manufacturer entered the market.[6] In the United Kingdom 2.5 mg of injectable solution costs the NHS about 4 pounds as of 2020.[4]

References[edit]

  1. ^ a b c d e f g h i j k "Droperidol Monograph for Professionals". Drugs.com. Archived from the original on 26 March 2016. Retrieved 13 October 2020.
  2. ^ a b Thomas, MC; Musselman, ME; Shewmaker, J (February 2015). "Droperidol for the treatment of acute migraine headaches". The Annals of pharmacotherapy. 49 (2): 233–40. doi:10.1177/1060028014554445. PMID 25416184.
  3. ^ "Droperidol (Inapsine) Use During Pregnancy". Drugs.com. Archived from the original on 29 October 2020. Retrieved 13 October 2020.
  4. ^ a b c BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 452. ISBN 9780857113658.
  5. ^ a b c Richards, JR; Schneir, AB (May 2003). "Droperidol in the emergency department: is it safe?". The Journal of emergency medicine. 24 (4): 441–7. doi:10.1016/s0736-4679(03)00044-1. PMID 12745049.
  6. ^ "Droperidol Is Back (and Here's What You Need to Know)". ACEP Now. Archived from the original on 25 September 2020. Retrieved 13 October 2020.
Retrieved from "https://en.wikipedia.org/w/index.php?title=User:Mr._Ibrahem/Droperidol&oldid=1156297546"