User:Mr. Ibrahem/Droxidopa

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Mr. Ibrahem/Droxidopa
Clinical data
Pronunciationdrox" i doe' pa[1]
Trade namesNorthera
Other namesβ,3-Dihydroxytyrosine, L-DOPS,L-threo-dihydroxyphenylserine, L-threo-DOPS, SM-5688
AHFS/Drugs.comMonograph
MedlinePlusa614025
License data
Routes of
administration		By mouth
Legal status
Legal status
  • US: ℞-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability90%
MetabolismLiver
Elimination half-life1.5 hours
ExcretionKidney
Identifiers
  • (2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
Chemical and physical data
FormulaC9H11NO5
Molar mass213.189 g·mol−1
3D model (JSmol)
  • C1=CC(=C(C=C1[C@H]([C@@H](C(=O)O)N)O)O)O
  • InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
  • Key:QXWYKJLNLSIPIN-JGVFFNPUSA-Na
  (verify)

Droxidopa, sold under the brand name Northera, is a medication used to treat neurological causes of low blood pressure with standing.[1] These causes may include Parkinson disease, autonomic neuropathy, and multiple systemic atrophy.[1][2] It is taken by mouth.[1]

Common side effects include headache, dizziness, nausea, and high blood pressure.[1] Other side effects may include neuroleptic malignant syndrome or worsened heart failure.[1][2] Safety in pregnancy is unclear.[2] It works after being converted in the body to norepinephrine (noradrenaline).[1]

Droxidopa was approved for medical use in the United States in 2014.[2] It is not approved in either Europe or the United Kingdom.[3] It is available as a generic medication.[4] In the United States a month of medication at a dose of 300 mg per day costs about 740 USD as of 2021.[4]

References[edit]

  1. ^ a b c d e f g h i j "Droxidopa". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 27 December 2021.
  2. ^ a b c d "Droxidopa Monograph for Professionals". Drugs.com. Archived from the original on 26 September 2020. Retrieved 27 December 2021.
  3. ^ "Droxidopa". SPS - Specialist Pharmacy Service. 5 January 2016. Archived from the original on 11 January 2022. Retrieved 27 December 2021.
  4. ^ a b "Droxidopa Prices and Droxidopa Coupons - GoodRx". GoodRx. Archived from the original on 8 May 2016. Retrieved 27 December 2021.
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