User:Mr. Ibrahem/Estazolam

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Mr. Ibrahem/Estazolam
Clinical data
Trade namesProSom, Eurodin, Nuctalon, others
Other namesDesmethylalprazolam
AHFS/Drugs.comMonograph
MedlinePlusa691003
License data
Routes of
administration		By mouth
Drug classBenzodiazepines (BZDs)[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability93%
MetabolismLiver
Onset of action30 min[3]
Elimination half-life10–24 hours
Duration of actionUp to 8 hr[4]
ExcretionKidney
Identifiers
  • 8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Chemical and physical data
FormulaC16H11ClN4
Molar mass294.74 g·mol−1
3D model (JSmol)
  • ClC1=CC2=C(C=C1)N3C=NN=C3CN=C2C4=CC=CC=C4
  • InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2 checkY
  • Key:CDCHDCWJMGXXRH-UHFFFAOYSA-N checkY
  (verify)

Estazolam, sold under the brand name ProSom among others, is a medication used to treat trouble sleeping.[1] It is taken by mouth, before bed.[1] Effects may begin in 30 minutes and last for up to 8 hours.[3][4] Use is only recommended short term.[4]

Common side effects include dizziness, daytime sleepiness, and poor coordination.[1][6] Other side effects may include aggression, anaphylaxis, decreased breathing (respiratory depression), and suicide.[1] Use in pregnancy may harm the baby.[1] It is a benzodiazepines (BZDs) and is believed to work by affecting GABA.[1]

Estazolam was patented in 1968 and came into medical use in 1975.[7] It is not approved for use in the United Kingdom.[8] In the United States 30 tablets of 2 mg costs about 18 USD as of 2021.[9] In the United States it is a Schedule 4 controlled substance due to the concerns of abuse.[1]

References[edit]

  1. ^ a b c d e f g h i j "Estazolam Monograph for Professionals". Drugs.com. Archived from the original on 22 November 2021. Retrieved 16 December 2021.
  2. ^ "Estazolam tablet". DailyMed. 30 September 2020. Archived from the original on 29 October 2020. Retrieved 25 October 2020.
  3. ^ a b Cacho, Valerie; Lum, Esther (2 June 2021). Integrative Sleep Medicine. Oxford University Press. p. 376. ISBN 978-0-19-088542-7. Archived from the original on 11 January 2022. Retrieved 16 December 2021.
  4. ^ a b c Learning, Jones & Bartlett (11 November 2019). 2020 Nurse's Drug Handbook. Jones & Bartlett Learning. p. 438. ISBN 978-1-284-16790-0. Archived from the original on 11 January 2022. Retrieved 16 December 2021.
  5. ^ "Estazolam (Prosom) Use During Pregnancy". Drugs.com. 18 September 2020. Archived from the original on 3 December 2020. Retrieved 25 October 2020.
  6. ^ a b "Estazolam". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 16 December 2021.
  7. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 538. ISBN 9783527607495. Archived from the original on 2021-11-01. Retrieved 2021-09-30.
  8. ^ Encyclopedia of Analytical Science. Elsevier. 2 April 2019. p. 257. ISBN 978-0-08-101984-9. Archived from the original on 11 January 2022. Retrieved 16 December 2021. In the United Kingdom, Etizolam, licensed only for use in India, Italy, and Japan and appearing in both diverted, but predominantly illicitly manufactured tablets has become one of the most commonly seized benzodiazepines
  9. ^ "Estazolam Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 9 November 2016. Retrieved 16 December 2021.
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