User:Mr. Ibrahem/Fluorometholone

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Mr. Ibrahem/Fluorometholone
Clinical data
Trade namesEfflumidex, Flucon, FML Forte, others
Other namesFluorometholone acetate
AHFS/Drugs.comMonograph
MedlinePlusa682660
Pregnancy
category
  • C
Drug classCorticosteroid (glucocorticoid)[1][2]
Identifiers
  • (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Chemical and physical data
FormulaC22H29FO4
Molar mass376.468 g·mol−1
3D model (JSmol)
  • O=C(C)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](C)C[C@H]4[C@@H]2CC3)C)C
  • InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 checkY
  • Key:FAOZLTXFLGPHNG-KNAQIMQKSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fluorometholone, sold under the brand names Efflumidex among others, is a steroid used to treat inflammatory eye diseases such as allergic conjunctivitis and anterior uveitis.[1][3] It is used as an eye drop.[4]

Common side effects include increased eye pressure, blurry vision, eye irritation, and change in taste.[1] Other side effects may include cataracts and eye infection.[4] It is a corticosteroid, specifically a glucocorticoid.[1][2] It comes in two main forms fluorometholone and fluorometholone acetate.[1]

Fluorometholone was patented in 1959.[2] It is available as a generic medication.[5] In the United Kingdom 10 ml of solution costs the NHS about £3 as of 2021.[4] This amount in the United States costs about 42 USD.[5]

References[edit]

  1. ^ a b c d e f g "Fluorometholone Monograph for Professionals". Drugs.com. Archived from the original on 31 July 2020. Retrieved 14 December 2021.
  2. ^ a b c Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 566–. ISBN 978-1-4757-2085-3. Archived from the original on 1 August 2020. Retrieved 3 October 2021.
  3. ^ a b "FML Ophthalmic Ointment (fluorometholone) dose, indications, adverse effects, interactions... from PDR.net". www.pdr.net. Archived from the original on 28 September 2018. Retrieved 14 December 2021.
  4. ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1208. ISBN 978-0857114105.
  5. ^ a b "Fluorometholone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 14 December 2021.