User:Mr. Ibrahem/Fluticasone

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Mr. Ibrahem/Fluticasone
Clinical data
Other namesFluticasone propionate, fluticasone furoate
AHFS/Drugs.comInhaled: Monograph
Nose: Monograph
Routes of
administration		Intranasal, inhaled, topical
Drug classGlucocorticoid[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability0.51% (Intranasal)
Protein binding91.0%
MetabolismIntranasal
Liver (CYP3A4-mediated)
Elimination half-life10 hours
ExcretionEye
Identifiers
  • S-fluoromethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate
Chemical and physical data
FormulaC22H27F3O4S
Molar mass444.51 g·mol−1
3D model (JSmol)
  • O=C(SCF)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C
  • InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 checkY
  • Key:MGNNYOODZCAHBA-GQKYHHCASA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fluticasone is a steroid which is used to treat asthma, COPD, and allergic rhinitis.[1][2] For asthma and COPD it is used for long term management.[1] It is used by breathing it into the lungs or as a nasal spray.[1][2]

Common side effects of the inhaled form include upper respiratory tract infections, throat irritation, candidiasis, cough, and headache.[1] Commons side effects of the nasal spray include a brief period of burning, nosebleeds, nausea, and sore throat.[2] It comes in two main forms fluticasone propionate and fluticasone furoate.[3]

Fluticasone propionate was patented in 1980, and approved for medical use in 1990.[4] In the United Kingdom 60 doses of 250 micrograms for breathing in costs the NHS about £25.[3] In 2018, it was the sixteenth most commonly prescribed medication in the United States, with more than 34 million prescriptions.[5][6] It is also available in combination as fluticasone/formoterol and fluticasone/salmeterol, among others.[3]

References[edit]

  1. ^ a b c d e f g "Fluticasone (Systemic, Oral Inhalation) Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 14 December 2021.
  2. ^ a b c d e "Fluticasone (EENT) Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 14 December 2021.
  3. ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 278. ISBN 978-0857114105.
  4. ^ Fischer, János; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 487. ISBN 9783527607495. Archived from the original on 2019-02-28. Retrieved 2021-12-14.
  5. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 12 February 2021. Retrieved 18 February 2021.
  6. ^ "Fluticasone - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 18 February 2021.
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