User:Mr. Ibrahem/Fluvastatin
Clinical data | |
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Trade names | Lescol, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a694010 |
Pregnancy category |
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Routes of administration | By mouth (capsules, tablets) |
Drug class | Statin[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 24–30%[2][3] |
Protein binding | >98%[3] |
Metabolism | Liver: CYP2C9 (75%), CYP3A4 (20%), CYP2C8 (5%)[3][4] |
Elimination half-life | 1–3 hours (capsule), 9 hours (XR formulations)[3][4] |
Excretion | Faeces (95%), urine (5%)[3] |
Identifiers | |
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Chemical and physical data | |
Formula | C24H26FNO4 |
Molar mass | 411.473 g·mol−1 |
3D model (JSmol) | |
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Fluvastatin, sold under the brand name Lescol among others, is a medication used to treat high cholesterol and high triglycerides and prevent heart disease.[5][1] It is used together with diet and exercise.[1] It is taken by mouth.[5] Up to 4 weeks may be required for maximal effect.[1]
Common side effects include muscle pain, heart burn, nausea, and headaches.[1] Other side effects may include muscle breakdown, liver problems, high blood sugar, and memory problems.[1] Use during pregnancy may harm the baby.[1] It is a statin and works by blocking HMG-CoA reductase.[1]
Fluvastatin was patented in 1982 and approved for medical use in 1993.[6][1] It is on the World Health Organization's List of Essential Medicines as an alternative to simvastatin.[7] It is available as a generic medication.[5] In the United Kingdom 4 weeks of medication costs the NHS about £3 to 20 per month as of 2021.[5]
References[edit]
- ^ a b c d e f g h i j "Fluvastatin Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 13 December 2021.
- ^ Haberfeld H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag.
- ^ a b c d e Neuvonen PJ, Backman JT, Niemi M (2008). "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin". Clinical Pharmacokinetics. 47 (7): 463–74. doi:10.2165/00003088-200847070-00003. PMID 18563955. S2CID 11716425.
- ^ a b "Lescol, Lescol XR (fluvastatin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 18 March 2014. Retrieved 18 March 2014.
- ^ a b c d e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 218. ISBN 978-0857114105.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 472. ISBN 9783527607495. Archived from the original on 2020-08-19. Retrieved 2021-10-05.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.