User:Mr. Ibrahem/Ketotifen

Mr. Ibrahem/Ketotifen
Clinical data
Trade names	Zaditor, Zaditen
Other names	Ketotifen fumarate
AHFS/Drugs.com	Monograph
MedlinePlus	a604033
Pregnancy; category	AU: B1; ;
Routes of; administration	By mouth (tablets), topical eye drops
Drug class	H1-antihistamine, mast cell stabilizer
Legal status
Legal status	US: By mouth — withdrawn, was Rx-only; Eye drops — over-the-counter;
Pharmacokinetic data
Bioavailability	60%
Protein binding	75%
Metabolism	Hepatic
Elimination half-life	12 hours
Identifiers
	IUPAC name 4-(1-Methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one;
Chemical and physical data
Formula	C19H19NOS
Molar mass	309.43 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3c1sccc1C(\c2c(cccc2)C3)=C4/CCN(C)CC4;
	InChI InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3 ; Key:ZCVMWBYGMWKGHF-UHFFFAOYSA-N ;
	(verify)

Ketotifen, sold under the brand name Zaditor among others, is a medication used to treat allergic conjunctivitis and allergic rhinitis.^[2]^[1] It is taken by mouth or applied as an eye drop.^[2]^[1]

Common side effects, when taken by mouth, include anxiety, trouble sleeping, and irritability.^[2] Common side effects, when used as eye drops, include redness of the eyes, runny nose, and headache.^[3] While use is often not recommended, there is no evidence of harm in early pregnancy.^[2] It is a H₁-antihistamine and mast cell stabilizer.^[3]

Ketotifen was patented in 1970 and came into medical use in 1976.^[4] In the United Kingdom 60 pills of 1 mg costs the NHS about £8.^[2] In the United States a 5 ml bottle of eye drops costs about 7 USD.^[5]

References[edit]

^ ^a ^b ^c ^d "Zaditor- ketotifen fumarate solution". DailyMed. 13 February 2020. Archived from the original on 11 June 2021. Retrieved 4 September 2020.
^ ^a ^b ^c ^d ^e ^f ^g ^h BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 302. ISBN 978-0857114105.
^ ^a ^b ^c ^d "Ketotifen Monograph for Professionals". Drugs.com. Archived from the original on 11 June 2021. Retrieved 1 December 2021.
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 548. ISBN 9783527607495. Archived from the original on 2020-08-13. Retrieved 2021-07-12.
^ "Compare Ketotifen Prices - GoodRx". GoodRx. Archived from the original on 2020-11-23. Retrieved 2021-12-01.

[PI2021-1] "Zaditor- ketotifen fumarate solution". DailyMed. 13 February 2020. Archived from the original on 11 June 2021. Retrieved 4 September 2020.

[BNF81-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 302. ISBN 978-0857114105.

[AHFS2021-3] "Ketotifen Monograph for Professionals". Drugs.com. Archived from the original on 11 June 2021. Retrieved 1 December 2021.

[Fis2006-4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 548. ISBN 9783527607495. Archived from the original on 2020-08-13. Retrieved 2021-07-12.

[5] "Compare Ketotifen Prices - GoodRx". GoodRx. Archived from the original on 2020-11-23. Retrieved 2021-12-01.

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